Consequential exposure to hypothermia in gestational diabetic rats induces oxidative changes in the brain of offspring

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dc.contributor.authorSharief, Ren_US
dc.contributor.authorMahaboob, Aen_US
dc.contributor.authorP, MBen_US
dc.date.accessioned2020-09-24T07:56:52Z
dc.date.available2020-09-24T07:56:52Z
dc.date.issued2020-07
dc.description.abstractBackground: Prenatal stress is unique due to range of problems and can affect the embryo/fetus beginning with conception. Gestational diabetes mellitus is the concern for expectant-mothers wherein glucose intolerance with consistent hyperglycemia is a threatening factor during pregnancy. Objectives: In the event of multiple stressors posing their effects on intrauterine life and placenta being the target of increased sympathetic tone during gestation, there is a possibility of functional vulnerabilities that may contribute to the pathogenesis in post-natal life. Studying brain regional discrepancies in offspring might help to know the prenatal stress-induced variation in the antioxidant barrier and promoted oxidative stress. Materials and Methods: The changes occurring in oxidative stress indices in discrete brain regions of rat offspring born as a consequential exposure to gestational diabetes (streptozotocin induction) and cold stress (15 and 20°C) are assessed in this study. Results: The findings specify the involvement of cold-stress provoked induction of higher degree oxidative stress within brain compartments as evidenced by a decrease in antioxidant enzymes, namely, superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase, and GSH as well as increase in the concentration of malondialdehyde. Results highlight the synergistic actions of stressors due to the increased generation of free radicals. Cold stress at 15°C found to cause exacerbatory actions by depleting antioxidant enzymes in diabetic subjects than the exposures made at 20°C. Conclusion: The findings prove that cold stress is a crucial stimulus to a fetus during gestation and acts as a trigger of oxidative stress especially in diabetic subjects and can pose an adverse impact. These changes could partly explain the increased vulnerability of prenatally stressed subjects to functional disorders including deficits in memory and cognitive processes in later life.en_US
dc.identifier.affiliationsDepartment of Zoology, Bangalore University, Bengaluru, Karnataka, Indiaen_US
dc.identifier.affiliationsMedical Intern, Jawaharlal Nehru Medical College, Belagavi, Karnataka, Indiaen_US
dc.identifier.citationSharief R, Mahaboob A, P MB. Consequential exposure to hypothermia in gestational diabetic rats induces oxidative changes in the brain of offspring. International Journal of Medical Science and Public Health. 2020 Jul; 9(7): 407-413en_US
dc.identifier.issn2277-338X
dc.identifier.issn2320-4664
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/205656
dc.languageenen_US
dc.publisherInternational Journal of Medical Science and Public Healthen_US
dc.relation.issuenumber7en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org/10.5455/ijmsph.2020.07116202023072020en_US
dc.subjectGestational Diabetesen_US
dc.subjectCold Stressen_US
dc.subjectDeveloping Brainen_US
dc.subjectOxidative Stress Indicesen_US
dc.titleConsequential exposure to hypothermia in gestational diabetic rats induces oxidative changes in the brain of offspringen_US
dc.typeJournal Articleen_US
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