Treatment failure following large loop excision of the transformation zone for the treatment of cervical intraepithelial neoplasia at Rajavithi Hospital.

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dc.contributor.authorBoonlikit, Sathoneen_US
dc.contributor.authorJunghuttakarnsatit, Pojaneeen_US
dc.contributor.authorAsavapiriyanont, Suvannaen_US
dc.date.accessioned2009-05-27T21:15:01Z
dc.date.available2009-05-27T21:15:01Z
dc.date.issued2008-01-05en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractOBJECTIVE: To evaluate the treatment failure rate of large loop excision of the transformation zone (LLETZ) in the treatment of cervical intraepithelial neoplasia (CIN) and the risk of persistence or recurrence depending on the clinicopathologic factors. MATERIAL AND METHOD: Retrospective case-record review of 250 women who had a final diagnosis of CIN and underwent LLETZ in Rajavithi Hospitalfrom June 1st, 1998 to December 31st, 2003. Computerized files of these patients were then reviewed for clinicopathological follow-up results. RESULTS: Success rate of 86.8% was obtained. The incidence of treatment failure was 13.2%. The clinicopathologic factor associated with the persistence or recurrence was the presence of CIN at the margin of excision. Of 69 cases with incomplete excision (positive margin), treatment failure developed in 29.0%, compared to 5.2% in patients with complete excision (negative margins) (p < 0.001). Using multivariate analysis, incomplete excision and endocervical margin involvement of specimen were independent risk factors for the treatment failure of CIN. CONCLUSION: LLETZ is an effective treatment for CIN. Treatment failure rate is low. Positive surgical margin is a predictor of persistence or recurrence after LLETZ. Incomplete excision and endocervical margin involvement of specimen are significant independent risk factors.en_US
dc.description.affiliationDepartment of Obstetrics and Gynecology, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand.en_US
dc.identifier.citationBoonlikit S, Junghuttakarnsatit P, Asavapiriyanont S. Treatment failure following large loop excision of the transformation zone for the treatment of cervical intraepithelial neoplasia at Rajavithi Hospital. Journal of the Medical Association of Thailand. 2008 Jan; 91(1): 31-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/44460
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCervical Intraepithelial Neoplasia --pathologyen_US
dc.subject.meshDelivery, Obstetricen_US
dc.subject.meshFemaleen_US
dc.subject.meshGynecologic Surgical Procedures --methodsen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRecurrenceen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshThailanden_US
dc.subject.meshTreatment Failureen_US
dc.subject.meshTreatment Outcomeen_US
dc.subject.meshUterine Cervical Neoplasms --pathologyen_US
dc.titleTreatment failure following large loop excision of the transformation zone for the treatment of cervical intraepithelial neoplasia at Rajavithi Hospital.en_US
dc.typeJournal Articleen_US
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