Oral Antibiotics for Community–acquired Pneumonia with Chest- indrawing in Children Aged Below Five Years: A Systematic Review.

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dc.contributor.authorLodha, Rakesh
dc.contributor.authorRandev, Shivani
dc.contributor.authorKabra, Sushil K
dc.date.accessioned2016-11-29T10:25:33Z
dc.date.available2016-11-29T10:25:33Z
dc.date.issued2016-06
dc.description.abstractObjectives: To determine the efficacy of oral antibiotics in under-five children with pneumonia and chest indrawing. Methods: We included controlled clinical trials (randomized or quasi randomized) that compared the efficacy of oral antibiotics versus parenteral antibiotics for treatment of community- acquired pneumonia with chest-indrawing (severe pneumonia as defined by the World Health Organization’s guidelines) in children below 60 months of age. Data were extracted and managed using RevMan software. Main outcome variables were: treatment failure rate, relapse rate, death rate, need for hospitalization, and severe adverse effects. Results: We identified four randomized controlled trials involving 4400 children who were diagnosed to have severe pneumonia but were feeding well and not hypoxic. Baseline characteristics of children in the two treatment arms (oral and parenteral antibiotics) were similar. In two studies, oral antibiotics were administered on an ambulatory basis, while in two, oral antibiotics were used in hospitalized children. Failure rate in children receiving oral antibiotics was 13% (288/2208) while that in children receiving parenteral antibiotics was 13.8% (302/2183) (OR 0.93; 95% CI 0.78, 1.11). Failure rates were not affected by the type of oral antibiotic, or presence of wheeze. Relapse rates, hospitalization or serious adverse events were similar in the two groups. Conclusion: Children with tachypnea with chest-indrawing without signs/symptoms of very severe pneumonia may be treated with oral antibiotics.en_US
dc.identifier.citationRakesh Lodha, Shivani Randev and Sushil K Kabra. Oral Antibiotics for Community–acquired Pneumonia with Chest- indrawing in Children Aged Below Five Years: A Systematic Review. Indian Pediatrics. 2016 Jun; 53(6): 489-495.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/179052
dc.language.isoenen_US
dc.source.urihttps://www.indianpediatrics.net/june2016/june-489-495.htmen_US
dc.subjectAmbulatory treatmenten_US
dc.subjectAmoxicillinen_US
dc.subjectManagement, Outcomeen_US
dc.titleOral Antibiotics for Community–acquired Pneumonia with Chest- indrawing in Children Aged Below Five Years: A Systematic Review.en_US
dc.typeArticleen_US
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