The prevalence of colistin-resistant Gram-negative bacteria isolated from hospitalized patients with bacteremia

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dc.contributor.authorWichai, Santimaleeworagunen_US
dc.contributor.authorSudaluck, Thunyaharnen_US
dc.contributor.authorPiraporn, Juntanawiwaten_US
dc.contributor.authorNachadaporn, Thongnoyen_US
dc.contributor.authorSuddhi, Harindhanavudhien_US
dc.contributor.authorSuwapach, Nakeesathiten_US
dc.contributor.authorSaowaluk, Teschumroonen_US
dc.date.accessioned2020-10-16T08:56:46Z
dc.date.available2020-10-16T08:56:46Z
dc.date.issued2020-02
dc.description.abstractThis study sought to investigate the prevalence of colistin-resistant Gram-negative bacteria (CoR-GNB) amongPseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae isolated frompatients with bacteremia and to identify other antimicrobials as a potential therapy for CoR-GNB infections. Weretrospectively reviewed the data of non-repeated clinical bacterial isolates from patients admitted to PhramongkutklaoHospital during May 2017–April 2018. We obtained the minimum inhibitory concentrations (MICs) of the studiedisolates and interpreted the MIC values followed by the Clinical and Laboratory Standards Institute (CLSI) criteria. Outof 623 bacterial isolates, the prevalence of E. coli was predominantly high (349), followed by K. pneumoniae (150),P. aeruginosa (64), and A. baumannii (60). The CoR-GNB rates among E. coli, K. pneumoniae, A. baumannii, andP. aeruginosa were 2.9%, 17.3%, 5.0%, and 1.6%, respectively. Seven out of 26 colistin-resistant K. pneumoniaeisolates and seven out of 10 colistin-resistant E. coli isolates were still susceptible to carbapenems (the MICs forimipenem and meropenem were ≤1 µg/ml). Tigecycline and aminoglycosides might be the best therapeutic choicesagainst CoR-GNB. In conclusion, our findings confirmed a CoR-GNB prevalence of approximately 1.6%–17.3%,depending on the bacterial species. Certain available antimicrobials remain effective against CoR-GNB.en_US
dc.identifier.affiliationsDepartment of Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailanden_US
dc.identifier.affiliationsAntibiotic Optimization and Patient Care Project by Pharmaceutical Initiative for Resistant Bacteria and Infectious Diseases Working Group PIRBIG, Silpakorn University, Nakhon Pathom 73000, Thailand.en_US
dc.identifier.affiliationsFaculty of Medical Technology, Nakhonratchasima College, Nakhon Ratchasima 30000, Thailand.en_US
dc.identifier.affiliationsDivision of Microbiology, Department of Clinical Pathology, Phramongkutklao Hospital, Bangkok 10400, Thailanden_US
dc.identifier.affiliationsDepartment of Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.en_US
dc.identifier.affiliationsDepartment of Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.en_US
dc.identifier.affiliationsDepartment of Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.en_US
dc.identifier.affiliationsDepartment of Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.en_US
dc.identifier.citationWichai Santimaleeworagun, Sudaluck Thunyaharn, Piraporn Juntanawiwat, Nachadaporn Thongnoy, Suddhi Harindhanavudhi, Suwapach Nakeesathit, Saowaluk Teschumroon. The prevalence of colistin-resistant Gram-negative bacteria isolated from hospitalized patients with bacteremia. Journal of Applied Pharmaceutical Science. 2020 Feb; 2020 Feb: 056-059en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210687
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber2en_US
dc.relation.volume10en_US
dc.source.urihttps://dx.doi.org//10.7324/JAPS.2020.102009en_US
dc.subjectAntimicrobial susceptibilityen_US
dc.subjectcolistinen_US
dc.subjectminimum inhibitory concentrationen_US
dc.subjectpolymyxinsen_US
dc.subjectGram-negative bacteria.en_US
dc.titleThe prevalence of colistin-resistant Gram-negative bacteria isolated from hospitalized patients with bacteremiaen_US
dc.typeJournal Articleen_US
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