Serological investigation of malaria outbreak in Thar desert of Rajasthan.

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dc.contributor.authorRoy, Aen_US
dc.contributor.authorTyagi, Pen_US
dc.contributor.authorBiswas, Sen_US
dc.date.accessioned2000-06-24en_US
dc.date.accessioned2009-06-01T18:23:39Z
dc.date.available2000-06-24en_US
dc.date.available2009-06-01T18:23:39Z
dc.date.issued2000-06-24en_US
dc.description.abstractA serological investigation by a repeat cross-sectional survey was conducted in Thar desert (Rajasthan) during and after one year of malaria outbreak to determine malaria endemicity using ELISA as a tool. The assay was based on indirect ELISA to measure antibody levels against a nonapeptide R1 (EENVEHDA-cys) derived from Pf 155/Resa and Plasmodium falciparum crude antigen. Finger prick blood samples were collected from individuals belonging to all age groups. Sera were tested at already standardized optimum dilution to detect antigen specific immunoglobulin isotype. The mean ELISA O.D. values 0.153 for anti R1 peptide and 0.162 for anti Pf antigen reflected the seronegative profile, when the focal malaria outbreak occurred in 1994. A substantial increase in antibody levels was detected in individuals after one year showing mean ELISA values for anti-R1 and anti-Pf antigens as 0.52 and 0.58 and seropositivity as 75.2% and 52% respectively. Data obtained from the present study indicate that serological survey could be done to assess the situation in case of reappearing or disappearing status of malaria in a defined population.en_US
dc.description.affiliationMalaria Research Centre (ICMR), 22-Sham Nath Marg, Delhi-110 054.en_US
dc.identifier.citationRoy A, Tyagi P, Biswas S. Serological investigation of malaria outbreak in Thar desert of Rajasthan. Journal of Communicable Diseases. 2000 Jun; 32(2): 123-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/112191
dc.language.isoengen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibodies, Protozoan --blooden_US
dc.subject.meshDesert Climateen_US
dc.subject.meshDisease Outbreaksen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assay --methodsen_US
dc.subject.meshHumansen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshMalaria, Falciparum --diagnosisen_US
dc.subject.meshPlasmodium falciparum --immunologyen_US
dc.titleSerological investigation of malaria outbreak in Thar desert of Rajasthan.en_US
dc.typeJournal Articleen_US
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