Clobazam in refractory childhood epilepsy.

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dc.contributor.authorKalra, Veena
dc.contributor.authorSeth, Rachna
dc.contributor.authorMishra, Devendra
dc.contributor.authorSaha, Narayan C
dc.date.accessioned2012-10-26T09:08:03Z
dc.date.available2012-10-26T09:08:03Z
dc.date.issued2010-03
dc.description.abstractObjective. To evaluate the efficacy of clobazam in childhood refractory epilepsy and to characterize the adverse drug reaction profile in the Indian population. Methods. A cohort of 88 children with ‘refractory’ epilepsy was started on clobazam as add-on therapy. Diagnosis was established and seizure type recorded. Therapeutic response was recorded as ‘complete’, ‘good’, and ‘no response’. Observed side effects were classified as ‘mild’, ‘moderate’ and ‘severe’. Results. Most children were on at least two antiepileptics. Seizures most identified were either partial (36.3%) or generalized tonic-clonic (15.9%). The dose ranged from 0.3-2 mg/kg/day (average 1+0.2 mg/kg/day). Clobazam was effective against all seizure types with complete seizure control seen in 60.2% patients. Tolerance was seen in 5 (5.6%) patients. Side effects were seen in 23 (26%) patients and were ‘mild’ in 20 (86.9%) of them. Clobazam was stopped in three patients who developed ataxia, which resolved on stopping the drug. Conclusion. Clobazam was observed to be an effective broad-spectrum antiepileptic with ‘mild’ side effects in Indian children.en_US
dc.identifier.citationKalra Veena, Seth Rachna, Mishra Devendra, Saha Narayan C. Clobazam in refractory childhood epilepsy. Indian Journal of Pediatrics. 2010 Mar; 77(3): 263-266.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/142519
dc.language.isoenen_US
dc.source.urihttps://medind.nic.in/icb/t10/i3/icbt10i3p263.pdfen_US
dc.subjectClobazamen_US
dc.subjectNewer antiepilepticsen_US
dc.subjectRefractory epilepsyen_US
dc.subjectAdd-on therapyen_US
dc.subject.meshAnticonvulsants --therapeutic use
dc.subject.meshBenzodiazepines --therapeutic use
dc.subject.meshChild
dc.subject.meshDrug Resistance
dc.subject.meshDrug Therapy, Combination
dc.subject.meshEpilepsy --drug therapy
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshProspective Studies
dc.titleClobazam in refractory childhood epilepsy.en_US
dc.typeArticleen_US
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