Detection of HPV16 and 18 by in situ hybridization in precancerous and cancerous lesions of cervix.

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dc.contributor.authorChoudhury, Monishaen_US
dc.contributor.authorSingh, Smitaen_US
dc.date.accessioned2006-07-28en_US
dc.date.accessioned2009-05-29T13:26:53Z
dc.date.available2006-07-28en_US
dc.date.available2009-05-29T13:26:53Z
dc.date.issued2006-07-28en_US
dc.description.abstractFifty cervical biopsies from women with preinvasive and invasive malignancies of uterine cervix and ten normal cervical biopsies were examined for the presence of human papilloma virus (HPV) 16 and 18 DNA sequences by in situ hybridization (ISH) method with biotinylated DNA probes. The overall positivity of HPV DNA was 48% (24/50). The positivity of HPV 16 DNA for low grade squamous intraepithelial lesion (LSIL), high grade squamous intraepithelial lesions (HSIL) and squamous cell carcinoma (SCC) were 33.33%, 45.45%, 42.30% respectively. The positivity for HPV 18 DNA for LSIL, HSIL and SCC were 0%, 18.18%, 30.76% respectively. Two cases of cervical adenocarcinomas showed positivity for HPV 18 DNA only.en_US
dc.description.affiliationDepartment of Pathology, Lady Hardinge Medical College & Associated Hospitals, New Delhi. pannachoudhury@gmail.comen_US
dc.identifier.citationChoudhury M, Singh S. Detection of HPV16 and 18 by in situ hybridization in precancerous and cancerous lesions of cervix. Indian Journal of Pathology & Microbiology. 2006 Jul; 49(3): 345-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/75658
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshBiopsyen_US
dc.subject.meshBiotinylationen_US
dc.subject.meshCarcinoma, Squamous Cell --pathologyen_US
dc.subject.meshCervix Uteri --pathologyen_US
dc.subject.meshDNA Probesen_US
dc.subject.meshDNA, Viral --analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHuman papillomavirus 16 --geneticsen_US
dc.subject.meshHuman papillomavirus 18 --geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization --methodsen_US
dc.subject.meshPapillomavirus Infections --pathologyen_US
dc.subject.meshUterine Cervical Neoplasms --pathologyen_US
dc.titleDetection of HPV16 and 18 by in situ hybridization in precancerous and cancerous lesions of cervix.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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