The effects of carbamazepine on sperm morphology in wistar rats.

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dc.contributor.authorShetty, Akhila Jagadishen_US
dc.contributor.authorNarayana, Ken_US
dc.date.accessioned2007-07-18en_US
dc.date.accessioned2009-06-01T06:10:06Z
dc.date.available2007-07-18en_US
dc.date.available2009-06-01T06:10:06Z
dc.date.issued2007-07-18en_US
dc.description.abstractCarbamazepine (5 H-dibenz (b, f) azepine-5-carboxamide), is an antiepileptic drug which is expected to be administered regularly over a substantial part of patients lifetime. As the gender focus in epilepsy the later years has primarily been on women, there certainly is a lack of studies focused on the effects particular to men. The present study was aimed to investigate its effects on germ cell's by employing the sperm morphology assay. Twelve groups of male wistar rats were treated with sterile water 0.5 ml, cyclophosphamide (CP) 20 mg/kg, carbamazepine 9, 18, 36 mg/kg (i.p) and 2% gumacasia 0.25 ml/100 g respectively for 5 consecutive days at intervals of 24 hrs. Following the last exposure, on days 14 and 35 sperm morphology assay was conducted as per the standard procedure. Mann-Whitney 'U' test was used for statistical analysis and the level of significance was P<0.01. Neither carbamazepine nor cyclophosphamide induced formation of abnormally shaped sperms at 14 day time interval. Whereas on day 35, with 18 mg/kg dose level of carbamazepine there was an increase in the number of sperms with heads defects (P<0.01); Whereas in the other two dose levels the number of abnormally shaped sperms had decreased. 2% gumacasia increased the number of sperms with tail defects at day 35. (Mann-Whitney 'U' test). CONCLUSION: Carbamazepine and 2% gumacasia could be germ cell mutagens and could cause infertility on prolonged use therefore further studies with serum drug level estimations are needed.en_US
dc.description.affiliationDepartment of Pharmacology, Kasturba Medical College, Mangalore. shettyakhila@yahoo.comen_US
dc.identifier.citationShetty AJ, Narayana K. The effects of carbamazepine on sperm morphology in wistar rats. Indian Journal of Physiology and Pharmacology. 2007 Jul-Sep; 51(3): 255-60en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/107177
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnticonvulsants --administration & dosageen_US
dc.subject.meshCarbamazepine --administration & dosageen_US
dc.subject.meshCyclophosphamide --administration & dosageen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshEpididymis --drug effectsen_US
dc.subject.meshGum Arabic --administration & dosageen_US
dc.subject.meshInjections, Intraperitonealen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSperm Counten_US
dc.subject.meshSperm Head --drug effectsen_US
dc.subject.meshSperm Tail --drug effectsen_US
dc.subject.meshTime Factorsen_US
dc.titleThe effects of carbamazepine on sperm morphology in wistar rats.en_US
dc.typeJournal Articleen_US
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