A sensitive assay for anti-HIV-1 drug discovery in a biological safety level-2 laboratory.

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dc.contributor.authorYoosook, Cen_US
dc.contributor.authorReutrakul, Ven_US
dc.contributor.authorSantisuk, Ten_US
dc.contributor.authorChaichana, Sen_US
dc.contributor.authorPezzuto, J Men_US
dc.contributor.authorDong, Yen_US
dc.contributor.authorClanton, D Jen_US
dc.contributor.authorKiser, Ren_US
dc.contributor.authorStaley, Pen_US
dc.date.accessioned2009-05-27T15:34:46Z
dc.date.available2009-05-27T15:34:46Z
dc.date.issued1998-12-20en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractStudies involving infectious, wild type HIV-1 must be performed under strict BSL-3 practice. We have employed a defective (deltaTat/Rev)MC99 and cloned 1A2 line, ie, mutated HIV-1 and Tat/Rev transfected cells to verify anti-HIV-1 activity in a BSL-2 laboratory. A number of extracts from various parts of 11 species of plants were studied. Results were correlated with those of an anti-HIV-1 reverse transcriptase (RT) assay.en_US
dc.description.affiliationDepartment of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand.en_US
dc.identifier.citationYoosook C, Reutrakul V, Santisuk T, Chaichana S, Pezzuto JM, Dong Y, Clanton DJ, Kiser R, Staley P. A sensitive assay for anti-HIV-1 drug discovery in a biological safety level-2 laboratory. The Southeast Asian Journal of Tropical Medicine and Public Health. 1998 Dec; 29(4): 758-62en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/33137
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/1998-29-4/1998-29-4-758.pdfen_US
dc.subject.meshAnti-HIV Agentsen_US
dc.subject.meshBiological Assay --methodsen_US
dc.subject.meshCytoprotection --drug effectsen_US
dc.subject.meshDrug Designen_US
dc.subject.meshGiant Cells --drug effectsen_US
dc.subject.meshHIV Reverse Transcriptase --antagonists & inhibitorsen_US
dc.subject.meshHumansen_US
dc.subject.meshLaboratory Infection --prevention & controlen_US
dc.subject.meshPlant Extracts --therapeutic useen_US
dc.subject.meshReverse Transcriptase Inhibitorsen_US
dc.titleA sensitive assay for anti-HIV-1 drug discovery in a biological safety level-2 laboratory.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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