Dissecting the contradictory findings of angiotensin converting enzyme genetic polymorphism with blood pressure and hypertension.

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dc.contributor.authorZaman, M Men_US
dc.contributor.authorYoshiike, Nen_US
dc.contributor.authorTanaka, Hen_US
dc.date.accessioned2001-12-29en_US
dc.date.accessioned2009-05-27T03:47:25Z
dc.date.available2001-12-29en_US
dc.date.available2009-05-27T03:47:25Z
dc.date.issued2001-12-29en_US
dc.descriptionBangladesh Medical Research Council Bulletin. 27 references.en_US
dc.description.abstractThe studies on the association of deletion/insertion (D/I) polymorphism of angiotensin converting enzyme (ACE) gene with blood pressure and hypertension reported contradictory results. We review the articles that considered blood pressure or hypertension as the main outcome measure to have an overview of the situation. There is heterogeneity of allele frequencies of ACE locus among ethnic groups. In descending order of D allele frequencies, ethnic groups are: Gulf Bedouin (0.657), Black (0.597), White (0.577), Chinese (0.400), Japanese (0.377), Bangladeshi (0.374) and Indian Sikh (0.373). Multiple studies were available for the Caucasians and Japanese with relatively large sample sizes. Three out of five studies in the Caucasians found association either in males or in females with blood pressure or hypertension. None of the three Japanese studies observed an association. So, ACE locus may be considered a marker for blood pressure or hypertension in the Caucasians but not in the Japanese. This racial difference is not surprising, because heterogenecity of ACE activity according to ACE genotypes has been reported among ethnic groups, and important differences in environmental factors persist. Studies in other populations were either small or sampling procedures were not adequately described. Given that the studies varied in designs, settings, sample size, and adjustment for confounding variables, adequately powered large-scale multicentre, multi-ethnic population-based studies using same method are required to resolve this contradiction.en_US
dc.description.affiliationNational Centre for Control of Rheumatic Fever and Heart Diseases, Sher-e-Bangla Nagar, Dhaka.en_US
dc.identifier.citationZaman MM, Yoshiike N, Tanaka H. Dissecting the contradictory findings of angiotensin converting enzyme genetic polymorphism with blood pressure and hypertension. Bangladesh Medical Research Council Bulletin. 2001 Dec; 27(3): 90-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/491
dc.language.isoengen_US
dc.source.urihttps://www.banglajol.info/index.php/BMRCB/indexen_US
dc.subject.meshAdulten_US
dc.subject.meshBlood Pressure --geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension --ethnologyen_US
dc.subject.meshMaleen_US
dc.subject.meshPeptidyl-Dipeptidase A --geneticsen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.titleDissecting the contradictory findings of angiotensin converting enzyme genetic polymorphism with blood pressure and hypertension.en_US
dc.typeJournal Articleen_US
dc.typeMeta-Analysisen_US
dc.typeReviewen_US
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