HBeAg/anti-HBe, alanine aminotransferase and HBV DNA levels in HBsAg positive chronic carriers.

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dc.contributor.authorRabbi, Fareha Jesminen_US
dc.contributor.authorRezwan, Md Kamaren_US
dc.contributor.authorShirin, Tahminaen_US
dc.date.accessioned2008-08-06en_US
dc.date.accessioned2009-05-27T03:46:59Z
dc.date.available2008-08-06en_US
dc.date.available2009-05-27T03:46:59Z
dc.date.issued2008-08-06en_US
dc.descriptionBangladesh Medical Research Council Bulletin.en_US
dc.description.abstractSerum samples from a total of 72 chronic hepatitis B virus carriers were analysed by serological, biochemical and molecular assays. The aim was to evaluate the relationship of the serological and biochemical parameters with molecular markers in order to assess the infectivity of virus. Out of 72 chronic HBsAg positive carriers, 28 patients were HBeAg positive and anti-HBe negative, 38 patients were HBeAg negative and anti-HBe positive, only 3 patients were positive for both HBeAg and anti-HBe and the rest 3 patients were negative for both markers. Detectable HBV DNA lcvcl was found in 92.86% HBsAg-positive/anti-HBe negative patients along with raised alanine aminotransferase (ALT) level (67.86%) compared with HBeAg-negative/anti-HBe positive carriers (36.84%) (p value = 0.02) and out a total of 38 HBeAg-negative/anti-HBe positive carriers, 12 (31.58%) patients had detectable lcvel of HBV DNA. Among the 14 HBeAg-negative/anti-HBe positive patients with elevated ALT level, 8 (57.14%) had detectable HBV DNA whereas out of 24 HBeAg-negative/anti-HBe positive patients with normal ALT level only 4 (16.66%) had detectablc HBV DNA lcvel. Significantly high rate of detection of HBV DNA was seen among anti-HBe positive patients with raised ALT level compared with the patients with normal ALT level (p value = 0.01).en_US
dc.description.affiliationDepartment of Clinical Immunology, National Institute of Kidney Diseases and Urology, Sher-E-Bangla Nagar, Dhaka, Bangladesh. fjesminr@yahoo.comen_US
dc.identifier.citationRabbi FJ, Rezwan MK, Shirin T. HBeAg/anti-HBe, alanine aminotransferase and HBV DNA levels in HBsAg positive chronic carriers. Bangladesh Medical Research Council Bulletin. 2008 Aug; 34(2): 39-43en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/208
dc.language.isoengen_US
dc.source.urihttps://www.banglajol.info/index.php/BMRCB/indexen_US
dc.source.urihttps://www.banglajol.info/index.php/BMRCB/article/view/1173/1185en_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshAlanine Transaminase --analysisen_US
dc.subject.meshCarrier Stateen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDNA, Viral --analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis B --physiopathologyen_US
dc.subject.meshHepatitis B Antibodies --analysisen_US
dc.subject.meshHepatitis B Surface Antigens --analysisen_US
dc.subject.meshHepatitis B e Antigens --analysisen_US
dc.subject.meshHepatitis B virus --geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshIndonesia --epidemiologyen_US
dc.subject.meshLiver --immunologyen_US
dc.subject.meshLiver Function Testsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshYoung Adulten_US
dc.titleHBeAg/anti-HBe, alanine aminotransferase and HBV DNA levels in HBsAg positive chronic carriers.en_US
dc.typeJournal Articleen_US
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