Aspirin by virtue of its acidic property may act as teratogen in early chick embryo.

Simple item page
dc.contributor.authorKotwani, Aen_US
dc.contributor.authorMehta, V Len_US
dc.contributor.authorIyengar, Ben_US
dc.date.accessioned1995-04-01en_US
dc.date.accessioned2009-06-01T08:12:59Z
dc.date.available1995-04-01en_US
dc.date.available2009-06-01T08:12:59Z
dc.date.issued1995-04-01en_US
dc.description.abstractAspirin (acetylsalicyclic acid) was dissolved either in normal saline or in phosphate buffer and was used in two doses to find out whether teratogenic potential of aspirin in chick blastoderm model is due to its acidic property or due to drug action. Drug was injected sub-blastodermally by window technique in fresh embryonated eggs after 17 hours of incubation at 39 degrees C. Eggs were re-incubated and harvested at 40 hours. Normal development of embryos was seen with normal saline and percentage of normal embryos with 30 micrograms (pH-3.19) and 120 micrograms (pH-2.64) aspirin was 31.7 and 4.9 respectively. Buffer produced 80.8% normal embryos and buffered 30 micrograms (pH-6.87) and 120 micrograms (pH-6.69) aspirin produced 67.7% and 30.8% normal embryos respectively. Changing the pH of aspirin to near neutral decreased the defect induced by aspirin but a significant effect of aspirin was observed at higher dose which could be independent of pH action.en_US
dc.description.affiliationDepartment of Pharmacology, Maulana Azad Medical College, New Delhi.en_US
dc.identifier.citationKotwani A, Mehta VL, Iyengar B. Aspirin by virtue of its acidic property may act as teratogen in early chick embryo. Indian Journal of Physiology and Pharmacology. 1995 Apr; 39(2): 131-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108744
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAbnormalities, Drug-Induced --pathologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAspirin --toxicityen_US
dc.subject.meshBlastoderm --drug effectsen_US
dc.subject.meshBuffersen_US
dc.subject.meshChick Embryo --drug effectsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshHydrogen-Ion Concentrationen_US
dc.subject.meshNeural Tube Defects --chemically induceden_US
dc.subject.meshPhosphates --chemistryen_US
dc.subject.meshSaline Solution, Hypertonic --chemistryen_US
dc.subject.meshTissue Fixationen_US
dc.titleAspirin by virtue of its acidic property may act as teratogen in early chick embryo.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Physiology and Pharmacology