Cryptic PML-RARα positive acute promyelocytic leukemia with unusual morphology and cytogenetics.

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dc.contributor.authorGoyal, Manu
dc.contributor.authorDattatreya, Palinki S
dc.contributor.authorGoud, Irawathy
dc.contributor.authorMurthy, Sudha S
dc.date.accessioned2012-09-28T08:27:38Z
dc.date.available2012-09-28T08:27:38Z
dc.date.issued2010-10
dc.description.abstractAcute Promyelocytic Leukemia (APL) is different from other forms of acute myeloid leukemia (AML), to the reason being the potential devastating coagulopathy and the sensitivity to all-trans retinoic acid (ATRA) and arsenic trioxide (As 2 O 3 ). We hereby present a case of APL, morphologically distinct from the hypergranular APL; however, the flow cytometry revealed a characteristic phenotype showing dim CD45, bright CD13, bright CD33 and dim CD117 positivity. These were negative for CD34, HLA-DR, B-lymphoid and T-lymphoid lineage markers. Conventional cytogenetics revealed a distinct karyotype of a male with translocation t(4;15)(q34.2:q26.3). However, interphase florescence-in-situ hybridization (FISH) revealed PML/RARA fusion signal on chromosome 15 in 90% cells. The cryptic translocations may be missed on conventional cytogenetics, however, need to be picked by other techniques as FISH.en_US
dc.identifier.citationGoyal Manu, Dattatreya Palinki S, Goud Irawathy, Murthy Sudha S. Cryptic PML-RARα positive acute promyelocytic leukemia with unusual morphology and cytogenetics. Indian Journal of Pathology & Microbiology. 2010 Oct-Dec; 53(4): 817-819.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/141822
dc.language.isoenen_US
dc.source.urihttps://www.ijpmonline.org/article.asp?issn=0377-4929;year=2010;volume=53;issue=4;spage=817;epage=819;aulast=Goyalen_US
dc.subjectAcute promyelocytic leukemiaen_US
dc.subjectcytogeneticsen_US
dc.subjectflow cytometryen_US
dc.subjectflorescence-in-situ hybridizationen_US
dc.subjectcrypticen_US
dc.titleCryptic PML-RARα positive acute promyelocytic leukemia with unusual morphology and cytogenetics.en_US
dc.typeArticleen_US
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