Cryptic PML-RARα positive acute promyelocytic leukemia with unusual morphology and cytogenetics.
dc.contributor.author | Goyal, Manu | |
dc.contributor.author | Dattatreya, Palinki S | |
dc.contributor.author | Goud, Irawathy | |
dc.contributor.author | Murthy, Sudha S | |
dc.date.accessioned | 2012-09-28T08:27:38Z | |
dc.date.available | 2012-09-28T08:27:38Z | |
dc.date.issued | 2010-10 | |
dc.description.abstract | Acute Promyelocytic Leukemia (APL) is different from other forms of acute myeloid leukemia (AML), to the reason being the potential devastating coagulopathy and the sensitivity to all-trans retinoic acid (ATRA) and arsenic trioxide (As 2 O 3 ). We hereby present a case of APL, morphologically distinct from the hypergranular APL; however, the flow cytometry revealed a characteristic phenotype showing dim CD45, bright CD13, bright CD33 and dim CD117 positivity. These were negative for CD34, HLA-DR, B-lymphoid and T-lymphoid lineage markers. Conventional cytogenetics revealed a distinct karyotype of a male with translocation t(4;15)(q34.2:q26.3). However, interphase florescence-in-situ hybridization (FISH) revealed PML/RARA fusion signal on chromosome 15 in 90% cells. The cryptic translocations may be missed on conventional cytogenetics, however, need to be picked by other techniques as FISH. | en_US |
dc.identifier.citation | Goyal Manu, Dattatreya Palinki S, Goud Irawathy, Murthy Sudha S. Cryptic PML-RARα positive acute promyelocytic leukemia with unusual morphology and cytogenetics. Indian Journal of Pathology & Microbiology. 2010 Oct-Dec; 53(4): 817-819. | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/141822 | |
dc.language.iso | en | en_US |
dc.source.uri | https://www.ijpmonline.org/article.asp?issn=0377-4929;year=2010;volume=53;issue=4;spage=817;epage=819;aulast=Goyal | en_US |
dc.subject | Acute promyelocytic leukemia | en_US |
dc.subject | cytogenetics | en_US |
dc.subject | flow cytometry | en_US |
dc.subject | florescence-in-situ hybridization | en_US |
dc.subject | cryptic | en_US |
dc.title | Cryptic PML-RARα positive acute promyelocytic leukemia with unusual morphology and cytogenetics. | en_US |
dc.type | Article | en_US |
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