Antithrombin III activity in cerebrovascular accidents.

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dc.contributor.authorSingh, V Pen_US
dc.contributor.authorSingh, M Ken_US
dc.contributor.authorKumar, Ven_US
dc.contributor.authorSinha, M Ken_US
dc.contributor.authorDwivedi, R Cen_US
dc.contributor.authorRai, Men_US
dc.contributor.authorDube, Ben_US
dc.date.accessioned2003-03-04en_US
dc.date.accessioned2009-05-31T03:49:28Z
dc.date.available2003-03-04en_US
dc.date.available2009-05-31T03:49:28Z
dc.date.issued2003-03-04en_US
dc.description.abstractCerebrovascular accidents are commonly due to occlusive or haemorrhagic lesions. The present prospective study was planned to find out role of antithrombin in possible etiopathological process, which might predispose an individual for stroke. METHOD: Biological activity of antithrombin III was done by the method as described by Innerfield et al (1976). Immunological estimation of an antithrombin III was done by single radial immunodiffusion by the technique of Mancini et al modified by Fahey and Mckelvey. RESULTS: The biological and immunological activity of antithrombin III was measured in 98 patient of occlusive and 56 patients of haemorrhagic strokes. Significant depression in biological as well as immunological activity (p<0.001) was observed in occlusive stroke. In haemorrhagic stroke both, biological and immunological activity was increased. In follow up study, there was progressive normalization of both, biological as well as of immunological activity in both group. CONCLUSION: Decrease of antithrombin III in occlusive and increase in haemorrhagic stroke indicates that these changes have at least an additive role in the pathogenesis of stroke.en_US
dc.description.affiliationInstitute of Medical Sciences, Banaras Hindu University, Varanasi.en_US
dc.identifier.citationSingh VP, Singh MK, Kumar V, Sinha MK, Dwivedi RC, Rai M, Dube B. Antithrombin III activity in cerebrovascular accidents. Journal of the Association of Physicians of India. 2003 Mar; 51(): 268-71en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/94231
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntithrombin III --physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSerine Proteinase Inhibitors --physiologyen_US
dc.subject.meshStroke --etiologyen_US
dc.titleAntithrombin III activity in cerebrovascular accidents.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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