Allogeneic haematopoietic stem cell transplantation: The Army hospital experience.

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dc.contributor.authorNAIR, V
dc.contributor.authorSHARMA, A
dc.contributor.authorDAS, S
dc.contributor.authorSHARMA, S
dc.contributor.authorGROVER, N
dc.contributor.authorKAUR, J
dc.date.accessioned2015-02-24T09:53:13Z
dc.date.available2015-02-24T09:53:13Z
dc.date.issued2013-01
dc.description.abstractBackground. We analysed the results of allogeneic haematopoietic stem cell transplantation (HSCT) in various genetic disorders, bone marrow failures and haematological malignancies done from 2002 to 2010 at the Army Hospital, Research and Referral, Delhi. Methods. A total of 119 matched-related allogeneic- HSCTs (allo-HSCTs) were done in 114 patients (men 76, women 38) aged between 2 and 60 years. Peripheral blood stem cells (n=75) and bone marrow (n=43) were used as the source of stem cells. Results. The overall survival was 62.3% (71/114) at a median follow-up of 34 months. Graft versus host disease (GVHD) was seen in 42 (36.8%) patients; grade III/IV acute GVHD in 17 (15%) and chronic GVHD in 24 (21%) patients. There were 4 (3.5%) graft rejections and one nonengraftment. The overall mortality was 37.7% (n=43) and the main causes of death were GVHD (32%), infections (26%), relapse (23%) and regimen-related toxicity (11%). Conclusion. Our results are comparable to published data in most disease conditions. With improvements in GVHD prophylaxis and better supportive care, we need to further reduce our mortality and morbidity.en_US
dc.identifier.citationNAIR V, SHARMA A, DAS S, SHARMA S, GROVER N, KAUR J. Allogeneic haematopoietic stem cell transplantation: The Army hospital experience. National Medical Journal of India. 2013 Jan-Feb ; 26 (1): 6-11.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/156319
dc.language.isoenen_US
dc.source.urihttps://nmji.in/archives/Volume-26/Issue-1/Original-Article-I.pdfen_US
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshBone Marrow Diseases --therapy
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshFemale
dc.subject.meshGenetic Diseases, Inborn --therapy
dc.subject.meshGraft Rejection --etiology
dc.subject.meshGraft vs Host Disease --etiology
dc.subject.meshHematologic Neoplasms --therapy
dc.subject.meshHematopoietic Stem Cell Transplantation -adverse effects
dc.subject.meshHospitals, Military
dc.subject.meshHumans
dc.subject.meshIndia
dc.subject.meshKaplan-Meier Estimate
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshSurvival Rate
dc.subject.meshTransplantation, Homologous
dc.subject.meshYoung Adult
dc.titleAllogeneic haematopoietic stem cell transplantation: The Army hospital experience.en_US
dc.typeArticleen_US
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