Cold bandage contact lens use reduces post-photorefractive keratectomy or corneal collagen-crosslinking pain perception in patients

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dc.contributor.authorShetty, Rohiten_US
dc.contributor.authorShetty, Narenen_US
dc.contributor.authorShirodkar, Sailieen_US
dc.contributor.authorAshok, Nikhilen_US
dc.contributor.authorSethu, Swaminathanen_US
dc.contributor.authorGhosh, Arkasubhraen_US
dc.contributor.authorKhamar, Poojaen_US
dc.date.accessioned2023-08-25T06:37:07Z
dc.date.available2023-08-25T06:37:07Z
dc.date.issued2023-05
dc.description.abstractPurpose: To compare post?operative pain perception using bandage contact lens (BCL) stored at 2–8?C (Cold BCL, CL?BCL) or room temperature (23 – 25?C, RT?BCL) after photorefractive keratectomy (PRK) or corneal collagen?crosslinking (CXL) and determine status of nociception associated factors. Methods: In this prospective interventional study, 56 patients undergoing PRK for refractive correction and 100 keratoconus (KC) undergoing CXL were recruited following approval from the institutional ethics committee with informed consent. Patients undergoing bilateral PRK received RT?BCL on one eye and CL?BCL on the other. Pain was graded by Wong–Baker scoring on the first post?operative day (PoD1). Expression of transient receptor potential channels (TRPV1, TRPA1, TRPM8), calcitonin gene?related peptide (CGRP) and IL?6 was measured in cellular content from used BCLs collected on PoD1. Equal number of KC patients received RT?BCL or CL?BCL post?CXL. Pain was graded by Wong–Baker scoring on PoD1. Results: Pain scores on PoD1 were significantly (P < 0.0001) reduced in subjects receiving CL?BCL (Mean ± SD: 2.6 ± 2.1) compared to RT?BCL (6.0 ± 2.4) post?PRK. 80.4% of subjects reported reduced pain scores with CL?BCL. 19.6% reported no change or increased pain scores with CL?BCL. TRPM8 expression was significantly (P < 0.05) increased in BCL of subjects reporting reduced pain with CL?BCL compared to those who did not. Pain scores on PoD1 were significantly (P < 0.0001) reduced in subjects receiving CL?BCL (3.2 ± 2.1) compared to RT?BCL (7.2 ± 1.8) post?CXL. Conclusion: The simple approach of using a cold BCL post?operatively substantially reduced pain perception and could overcome post?operative pain?related limited acceptance of PRK/CXL.en_US
dc.identifier.affiliationsDepartments of Cornea and Refractive Surgery, Narayana Nethralaya, Bangalore, Karnataka, Karnataka, Indiaen_US
dc.identifier.affiliationsCataract and Refractive Surgery, Narayana Nethralaya, Bangalore, Karnataka, Karnataka, Indiaen_US
dc.identifier.affiliationsGROW Research Laboratories, Narayana Nethralaya Foundation, Bangalore, Karnataka, Indiaen_US
dc.identifier.citationShetty Rohit, Shetty Naren, Shirodkar Sailie, Ashok Nikhil, Sethu Swaminathan, Ghosh Arkasubhra, Khamar Pooja. Cold bandage contact lens use reduces post-photorefractive keratectomy or corneal collagen-crosslinking pain perception in patients. Indian Journal of Ophthalmology. 2023 May; 71(5): 1855-1861en_US
dc.identifier.issn1998-3689
dc.identifier.issn0301-4738
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/225069
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber5en_US
dc.relation.volume71en_US
dc.source.urihttps://doi.org/10.4103/IJO.IJO_2757_22en_US
dc.subjectBandage contact lensen_US
dc.subjectcolden_US
dc.subjectcollagen?crosslinkingen_US
dc.subjectpainen_US
dc.subjectphotorefractive keratectomyen_US
dc.subjectTRP channelen_US
dc.titleCold bandage contact lens use reduces post-photorefractive keratectomy or corneal collagen-crosslinking pain perception in patientsen_US
dc.typeJournal Articleen_US
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