Prevalence of extended-spectrum beta-lactamases among Escherichia coli and Klebsiella pneumoniae isolates in a tertiary care hospital.

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dc.contributor.authorAgrawal, Parulen_US
dc.contributor.authorGhosh, A Nen_US
dc.contributor.authorKumar, Satishen_US
dc.contributor.authorBasu, Ben_US
dc.contributor.authorKapila, Ken_US
dc.date.accessioned2008-01-18en_US
dc.date.accessioned2009-05-29T11:55:18Z
dc.date.available2008-01-18en_US
dc.date.available2009-05-29T11:55:18Z
dc.date.issued2008-01-18en_US
dc.description.abstractExtended-spectrum beta-lactamases (ESBLs) continue to be a major problem in clinical setups the world over, conferring resistance to the expanded-spectrum cephalosporins. Knowledge about their prevalence is essential to guide towards appropriate antibiotic treatment. The aim of the present study is to determine the prevalence of ESBL producers among Escherichia coli and Klebsiella pneumoniae isolates at a tertiary care institution. A total of 357 clinical isolates comprising E. coli (n = 181) and K. pneumoniae (n = 176) were recovered from various clinical samples over a period of six months from April to September 2006. Antibiogram profile of these isolates was determined to commonly used antibiotics, along with screening for ESBL production by the screening test as recommended by the Clinical Laboratory Standards Institute (CLSI). Isolates which showed positive results with screening test were shortlisted for confirmatory tests of ESBL production. Two tests were performed: phenotypic confirmatory test with combination disk and the minimum inhibitory concentration (MIC) reduction test. Out of 357 isolates of E. coli and K. pneumoniae screened for ESBL production, 120 were found to be potential ESBL producers. Of these, 80 isolates were confirmed to be ESBL producers. Thus the prevalence of ESBL-producing isolates of E. coli and K. pneumoniae was found to be 22% (80 out of 357). This was significantly lower than the data available from other hospitals.en_US
dc.description.affiliationDepartment of Microbiology, Armed Forces Medical College, Pune, India. parul_dr@yahoo.co.inen_US
dc.identifier.citationAgrawal P, Ghosh AN, Kumar S, Basu B, Kapila K. Prevalence of extended-spectrum beta-lactamases among Escherichia coli and Klebsiella pneumoniae isolates in a tertiary care hospital. Indian Journal of Pathology & Microbiology. 2008 Jan-Mar; 51(1): 139-42en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/74037
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshAnti-Bacterial Agents --pharmacologyen_US
dc.subject.meshEscherichia coli --drug effectsen_US
dc.subject.meshEscherichia coli Infections --microbiologyen_US
dc.subject.meshHospitalsen_US
dc.subject.meshHumansen_US
dc.subject.meshKlebsiella Infections --microbiologyen_US
dc.subject.meshKlebsiella pneumoniae --drug effectsen_US
dc.subject.meshMicrobial Sensitivity Testsen_US
dc.subject.meshbeta-Lactam Resistanceen_US
dc.subject.meshbeta-Lactamases --metabolismen_US
dc.titlePrevalence of extended-spectrum beta-lactamases among Escherichia coli and Klebsiella pneumoniae isolates in a tertiary care hospital.en_US
dc.typeJournal Articleen_US
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