Changing patterns and re-distribution of antigen in poorly differentiated carcinomas: its implications in tumour diagnosis.

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dc.contributor.authorPervez, Sen_US
dc.contributor.authorHasan, S Hen_US
dc.contributor.authorAijaz, Fen_US
dc.contributor.authorAziz, S Aen_US
dc.contributor.authorAmirali, Yen_US
dc.contributor.authorShaikh, Hen_US
dc.date.accessioned1998-01-15en_US
dc.date.accessioned2009-05-29T11:20:18Z
dc.date.available1998-01-15en_US
dc.date.available2009-05-29T11:20:18Z
dc.date.issued1998-01-15en_US
dc.description.abstractThe variability of expression of tumour-associated antigens via either antigenic heterogeneity or antigenic modulation presents a basic problem in immunohistochemical diagnosis of poorly/undifferentiated tumours. This work was designed to study antigenic expression on human resected epithelial tumours by a panel of most widely used antibodies (EMA, CEA, AUAI & Cytokeratin) in relation to tumour differentiation and polarization. It was observed that poorly differentiated carcinoma with loss of polarity show homogeneous membrane staining (with antibodies against EMA, CEA & AUAI) in contrast to either apical (luminal) or basolateral membrane staining in well differentiated counterparts. Biochemical studies have shown that apical and basolateral epithelial cell membrane domains have a characteristic set of glycoproteins. Tight junctions are essential for maintaining this functional polarization. It was concluded that structural and functional abnormalities of tight junctions in poorly differentiated carcinomas results in loss of polarity with progressive invasion of the cell surface by antigenic glycoprotein and resultant homogeneous individual cell antigenic expression in poorly differentiated carcinomas. This study demonstrates that antigenic expression on tumour cells is not static, but dynamic and heterogeneity of antigenic expression may well be due to biological factors such as spatial configuration of the lesion.en_US
dc.description.affiliationDepartment of Pathology, Aga Khan University Hospital, Karachi, Pakistan.en_US
dc.identifier.citationPervez S, Hasan SH, Aijaz F, Aziz SA, Amirali Y, Shaikh H. Changing patterns and re-distribution of antigen in poorly differentiated carcinomas: its implications in tumour diagnosis. Indian Journal of Pathology & Microbiology. 1998 Jan; 41(1): 55-66en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/73405
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshAdenocarcinoma --diagnosisen_US
dc.subject.meshAntibodies, Monoclonalen_US
dc.subject.meshAntigens, Neoplasm --analysisen_US
dc.subject.meshCell Differentiationen_US
dc.subject.meshCell Polarityen_US
dc.subject.meshEpithelium --pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshStaining and Labelingen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.subject.meshTumor Markers, Biological --analysisen_US
dc.titleChanging patterns and re-distribution of antigen in poorly differentiated carcinomas: its implications in tumour diagnosis.en_US
dc.typeJournal Articleen_US
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