Duchenne muscular dystrophy: case series of rare inherited muscular disorder
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Date
2022-12
Journal Title
Journal ISSN
Volume Title
Publisher
Medip Academy
Abstract
Duchenne muscular dystrophy (DMD) is a rare muscular disordercaused by mutation of gene encoding dystrophin protein which required for maintaining muscle stability during contraction. DMD occurs in 1 in 5000 male live births and characterized by progressive muscular weakness associated with motor development delay, loss of independent ambulation, respiratory failure, and cardiomyopathy. We present a case series of 3 DMD patients who were diagnosed at Prof. dr. I.G.N.G. Ngoerah general hospital,Denpasar over a period of four years (2019-2022). Clinical manifestation of patients includes progressive weakness of lower extremities and difficulty to stand up from sitting position. Physical examination revealed pseudohypertrophy of calf, winged scapula, positive Goweræ¯ sign, and waddling gait in all three cases. Supporting examination showed an increase of alanine transaminaseand aspartate transaminase5.6 times and 6.1 times the upper limit of normal, respectively. Definitive diagnosis of all patient was made based on immunohistochemistry staining which revealed an absent of dystrophin protein around muscle membrane
Description
Keywords
DMD, Dystrophinopathies, Inherited disorder
Citation
Dewi I. Gusti Ayu Sri Mahendra, Seputra Desak Made Cittarasmi Saraswati. Duchenne muscular dystrophy: case series of rare inherited muscular disorder. International Journal of Advances in Medicine. 2022 Dec; 9(12): 1194-1197