Effect of Antenatal Dexamethasone Administration on Foetal and Uteroplacental Doppler Waveforms in Women at Risk of Spontaneous Preterm Birth: A Prospective Study

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dc.contributor.authorAhmed, A. Yassinen_US
dc.contributor.authorAbosrea, Mahmouden_US
dc.contributor.authorEdris, Yehiaen_US
dc.contributor.authorAbdelaziz, Lobnaen_US
dc.date.accessioned2020-09-24T07:24:55Z
dc.date.available2020-09-24T07:24:55Z
dc.date.issued2019-01
dc.description.abstractIntroduction: The effects of antenatal dexamethasone onfoetal and uteroplacental circulation as measured by Dopplerwaveform has gained more attention recently. In the presentstudy, we aimed to assess the change in foetal anduteroplacental circulation following antenatal dexamethasoneadministration to high-risk pregnant women.Methods: We conducted a prospective cohort study on 50pregnant women with high risk of preterm birth within thegestational age from 24 to 34 weeks. Two doses ofdexamethasone was administrated and. Doppler velocitywaveforms were obtained from the umbilical artery, fetal middlecerebral artery (MCA), fetal descending aorta and maternaluterine arteries Data analysis was carried out using SPSSversion 22 for Microsoft Windows.Results: The mean age of the included women were 27.9 ±4.8years while the mean parity was 2.14 ±1.4. Eighty percent ofthe children were alive at delivery. In terms of Doppler Indices,the umbilical artery pulsatility index (PI) and resistive indexshowed a statistically significant reduction afterDexamethasone administration (p <0.001). Similarly, theuterine and MCA arteries PI and RI showed a statisticallysignificant reduction after Dexamethasone administration (p<0.001). In terms of Cerebro-umbilical ratio (CUR), the ratioshowed a statistically significant increase after Dexamethasoneadministration (p =0.015). The CUR increased significantlyafter dexamethasone administration to reach 2.1 ±0.33. Onlyone patient had abnormal velicometry before and afterdexamethasone.Conclusion: In conclusion, the present study shows thatantenatal dexamethasone administration significantly improvethe fetal and uteroplacental hemodynamics, assessed byDoppler, among women with risk of preterm laboren_US
dc.identifier.affiliationsDepartment of Obstetrics & Gynaecology, Faculty of Medicine, Banha University, Egypt.en_US
dc.identifier.citationAhmed A. Yassin, Abosrea Mahmoud, Edris Yehia, Abdelaziz Lobna. Effect of Antenatal Dexamethasone Administration on Foetal and Uteroplacental Doppler Waveforms in Women at Risk of Spontaneous Preterm Birth: A Prospective Study. International Journal of Medical Research Professionals. 2019 Jan; 5(1): 131-135en_US
dc.identifier.issn2454-6364
dc.identifier.issn2454-6356
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/203184
dc.languageenen_US
dc.publisherIbn Sina Academy of Medieval Medicine & Sciencesen_US
dc.relation.issuenumber1en_US
dc.relation.volume5en_US
dc.source.urihttps://dx.doi.org//10.21276/ijmrp.2019.5.1.028en_US
dc.subjectPreterm Labour; Dexamethasone; Doppler Waveforms.en_US
dc.titleEffect of Antenatal Dexamethasone Administration on Foetal and Uteroplacental Doppler Waveforms in Women at Risk of Spontaneous Preterm Birth: A Prospective Studyen_US
dc.typeJournal Articleen_US
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