Exchange transfusion in septic neonates with sclerema: effect on immunoglobulin and complement levels.

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dc.contributor.authorSadana, Sen_US
dc.contributor.authorMathur, N Ben_US
dc.contributor.authorThakur, Aen_US
dc.date.accessioned1997-01-01en_US
dc.date.accessioned2009-05-27T05:05:38Z
dc.date.available1997-01-01en_US
dc.date.available2009-05-27T05:05:38Z
dc.date.issued1997-01-01en_US
dc.description.abstractOBJECTIVE: To study the effect of exchange transfusion (ET) on the levels of immunoglobulins (Ig) and C3 in neonatal sepsis with sclerema. DESIGN: Randomized controlled trial in a referral neonatal unit of a teaching hospital. SUBJECTS: Consecutive culture positive septic neonates with sclerema were enrolled and were randomized to undergo ET (study group, n = 20) or no ET (controls, n = 20). RESULTS: Mortality was 50% in the study group and 95% in controls. Gram negative organisms accounted for 85% in study group and 90% in controls. IgG, IgA and IgM levels rose significantly while C3 levels did not show significant rise 12-24 hours after ET. Ig and C3 levels did not change significantly in the controls. CONCLUSION: ET with fresh whole blood in septicemic newborns with sclerema improves survival, particularly in the more premature group and significantly enhances, IgG, IgA and IgM levels.en_US
dc.description.affiliationDepartment of Pediatrics, Maulana Azad Medical College, New Delhi.en_US
dc.identifier.citationSadana S, Mathur NB, Thakur A. Exchange transfusion in septic neonates with sclerema: effect on immunoglobulin and complement levels. Indian Pediatrics. 1997 Jan; 34(1): 20-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/8121
dc.language.isoengen_US
dc.source.urihttps://indianpediatrics.neten_US
dc.subject.meshBacteremia --complicationsen_US
dc.subject.meshComplement System Proteins --metabolismen_US
dc.subject.meshExchange Transfusion, Whole Blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulins --blooden_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshInfant, Prematureen_US
dc.subject.meshMaleen_US
dc.subject.meshSclerema Neonatorum --complicationsen_US
dc.subject.meshStatistics, Nonparametricen_US
dc.subject.meshSurvival Rateen_US
dc.titleExchange transfusion in septic neonates with sclerema: effect on immunoglobulin and complement levels.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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