Development and Evaluation of Sustained Release Matrix Tablets of Indapamide using Methocel K15M CR.
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Date
2013-05
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Abstract
In the present study an attempt has been taken to develop Indapamide sustained release matrix tablet using
Methocel K15M CR by direct compression method. Various amount of polymer was used in the five proposed
formulations (F-1to F-5) for the study of release rate retardant effect at 26.47%, 29.41%, 32.35%, 35.29% and
38.24% of total weight of tablet matrix respectively. Then the tablets were evaluated in terms of their physical
parameters (weight variation, hardness, friability and thickness), drug content and in vitro release studies. All the
formulations showed compliance with pharmacopoeial standards. The in vitro dissolution study were conducted
using USP 30 dissolution apparatus type I (Basket method) in 900 ml phosphate buffer (pH 6.8) at 100 rpm for a
total period of 24 hours. The release mechanisms were explored and explained by Zero order, Higuchi, First
order and Korsmeyer-Peppas equations. Based on the dissolution data comparison with innovator brand
formulation F-3 (32.35% Methocel K15M CR w/w) was found as the best formulation. The drug release profile
of this formulation was well controlled and uniform throughout the dissolution studies. The drug release of
formulation F-3 followed First Order kinetic model (r2 = 0.99) and the mechanism was found to be non-
Fickian/anomalous according to Korsmeyer-Peppas equation.
Description
Keywords
Indapamide, Direct compression, Sustained release, Methocel K15M CR, Release Kinetics
Citation
Hossain Md Anwar, Alam Shahinul, Paul Prasanta. Development and Evaluation of Sustained Release Matrix Tablets of Indapamide using Methocel K15M CR. Journal of Applied Pharmaceutical Science. 2013 May; 3(5): 85-90.