Efficacy of primary hepatitis B immunization in children with acute lymphoblastic leukemia.

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dc.contributor.authorBaytan, Birolen_US
dc.contributor.authorGunes, Adalet Meralen_US
dc.contributor.authorGunay, Unsalen_US
dc.date.accessioned2008-04-03en_US
dc.date.accessioned2009-05-27T05:51:24Z
dc.date.available2008-04-03en_US
dc.date.available2009-05-27T05:51:24Z
dc.date.issued2008-04-03en_US
dc.description.abstractBACKGROUND: Children with acute lymphoblastic leukemia (ALL) carry a high risk of hepatitis B virus (HIV) infection. The present study was conducted to see if prior routine hepatitis B vaccine received as a part of national immunization program could prevent HBV infection in these children. METHODOLOGY: Ninety-six children with ALL were screened for HBV. Children were divided into three groups according to their initial HBV serology; previously vaccinated children (Group I) (n=34) previously unvaccinated and seronegative children (Group II) (n=56),and unvaccinated but HBsAg negative and anti-HBs positive children (group III) (n=6). Sixty-seven of 96 (69.7%) children received vaccination. The schedule was initiated during the third month of maintenance therapy and each course consisted of three doses given at one month interval. RESULTS: Anti-HBs seroconversion following the first course of three doses of hepatitis B vaccination in group I, II and III was 57%, 33% and 100%, respectively. It increased to 97% in Group I, 62.5% in Group II, 100% in Group III. HBsAg positivity was found in 11 children (11.5%) and all of them developed chronic hepatitis B. Ten of them were in Group II whereas only one child was in Group I (P<0.04). CONCLUSION: This data reveals that routine HBV vaccination within the national immunization program plays an important role in decreasing subsequent hepatitis B infection in children with ALL.en_US
dc.description.affiliationDepartment of Pediatric Hematology, Uludag University, Medical Faculty, bursa, Turkey. baytanbirol@yahoo.comen_US
dc.identifier.citationBaytan B, Gunes AM, Gunay U. Efficacy of primary hepatitis B immunization in children with acute lymphoblastic leukemia. Indian Pediatrics. 2008 Apr; 45(4): 265-70en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/13549
dc.language.isoengen_US
dc.source.urihttps://indianpediatrics.neten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshChilden_US
dc.subject.meshChild Welfareen_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshFemaleen_US
dc.subject.meshHealth Statusen_US
dc.subject.meshHepatitis B --immunologyen_US
dc.subject.meshHepatitis B Antibodiesen_US
dc.subject.meshHepatitis B Vaccinesen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma --physiopathologyen_US
dc.subject.meshRemission Inductionen_US
dc.subject.meshRisk Factorsen_US
dc.titleEfficacy of primary hepatitis B immunization in children with acute lymphoblastic leukemia.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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