Harnessing the innate immune system by revolutionizing macrophage-mediated cancer immunotherapy

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dc.contributor.authorREGHU, GAYATRIen_US
dc.contributor.authorVEMULA, PRAVEEN KUMARen_US
dc.contributor.authorBHAT, SARITA GANAPATHYen_US
dc.contributor.authorNARAYANAN, SREEJAen_US
dc.date.accessioned2024-11-30T11:24:43Z
dc.date.available2024-11-30T11:24:43Z
dc.date.issued2024-06
dc.description.abstractImmunotherapy is a promising and safer alternative to conventional cancer therapies. It involves adaptive T-cell therapy, cancer vaccines, monoclonal antibodies, immune checkpoint blockade (ICB), and chimeric antigen receptor (CAR) based therapies. However, most of these modalities encounter restrictions in solid tumours owing to a dense, highly hypoxic and immune-suppressive microenvironment as well as the heterogeneity of tumour antigens. The elevated intra-tumoural pressure and mutational rates within fast-growing solid tumours present challenges in efficient drug targeting and delivery. The tumour microenvironment is a dynamic niche infiltrated by a variety of immune cells, most of which are macrophages. Since they form a part of the innate immune system, targeting macrophages has become a plausible immunotherapeutic approach. In this review, we discuss several versatile approaches (both at pre-clinical and clinical stages) such as the direct killing of tumour-associated macrophages, reprogramming pro-tumour macrophages to anti-tumour phenotypes, inhibition of macrophage recruitment into the tumour microenvironment, novel CAR macrophages, and genetically engineered macrophages that have been devised thus far. These strategies comprise a strong and adaptable macrophage-toolkit in the ongoing fight against cancer and by understanding their significance, we may unlock the full potential of these immune cells in cancer therapy.en_US
dc.identifier.affiliationsDepartment of Biotechnology, Cochin University of Science and Technology, Kochi 682 022, Indiaen_US
dc.identifier.affiliationsInstitute for Stem Cell Science and Regenerative Medicine (inStem), Bengaluru 560 065, Indiaen_US
dc.identifier.affiliationsDepartment of Biotechnology, Cochin University of Science and Technology, Kochi 682 022, Indiaen_US
dc.identifier.affiliationsDepartment of Biotechnology, Cochin University of Science and Technology, Kochi 682 022, Indiaen_US
dc.identifier.citationREGHU GAYATRI, VEMULA PRAVEEN KUMAR, BHAT SARITA GANAPATHY, NARAYANAN SREEJA. Harnessing the innate immune system by revolutionizing macrophage-mediated cancer immunotherapy. Journal of Biosciences. 2024 Jun; 49: 1-12en_US
dc.identifier.issn0250-5991
dc.identifier.issn0973-7138
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/237981
dc.languageenen_US
dc.publisherThe Indian Academy of Sciencesen_US
dc.relation.volume49en_US
dc.source.urihttps://doi.org/10.1007/s12038-024-00441-yen_US
dc.subjectCancer immunologyen_US
dc.subjectCARTcellsen_US
dc.subjectimmunotherapyen_US
dc.subjectmacrophagesen_US
dc.subjecttumour-associated macrophagesen_US
dc.titleHarnessing the innate immune system by revolutionizing macrophage-mediated cancer immunotherapyen_US
dc.typeJournal Articleen_US
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