Effect of superdisintegrants and their mode of incorporation on disintegration time and release profile of carbamazepine from immediate release tablet.
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Date
2013-05
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Abstract
In this experiment the effect of mode of incorporation of some superdisintegrants such as sodium starch
glycolate, croscarmellose sodium, crospovidone (kollidon CL), ludiflash and Xanthan gum (XG) on dissolution
profile and disintegration time of carbamazepine (CBZ), apoorly water soluble drug was studied. The
superdisintegrants were incorporated by extragranularly, intragranularly and in direct compression method.
Different amount of superdisintegrants (1%, 3% and 6%) was incorporated in different formulations whereas all
the other excipients as well as the active drug remained same. The results indicated that sodium starch glycolate,
when incorporated extragranularly in wet granulation method significantly enhanced the release profile of CBZ.
Kollidon CL was the most effective superdisintegrant in decreasing disintegration time of different tablet
formulations (1.95 minutes when extragranularly incorporated). On the other hand, tablets prepared with SSG
were found most effective in % drug release irrespective of its mode of incorporation (99.99% when
extragranularly incorporated and 99.75 when intragranularly incorporated within one hour). Tablets prepared by
direct compression method also showed similar drug release with other methods but tablet hardness was found
lower. So addition of superdisintegrants in tablet formulation may be an effective technique to comply
compendial drug release.
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Keywords
Carbamazepine, super disintegrants, wet granulation, dry granulation, direct compression, disintegration time, release profile
Citation
Nazmi Mehrina, Islam S M Ashraful, Bhuiyan Mohiuddin Ahmed, Reza Md Selim. Effect of superdisintegrants and their mode of incorporation on disintegration time and release profile of carbamazepine from immediate release tablet. Journal of Applied Pharmaceutical Science. 2013 May; 3(5): 80-84.