Color Doppler imaging of the retrobulbar circulation and plasmatic biomarkers of vascular risk in age-related macular degeneration: A pilot study

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dc.contributor.authorRodrigo, Fen_US
dc.contributor.authorRuiz-Moreno, JMen_US
dc.contributor.authorGarcía, JBen_US
dc.contributor.authorTorregrosa, MEen_US
dc.contributor.authorSegura, JVen_US
dc.contributor.authorPiñero, DPen_US
dc.date.accessioned2020-04-10T01:57:59Z
dc.date.available2020-04-10T01:57:59Z
dc.date.issued2018-01
dc.description.abstractPurpose: To evaluate preliminarily and compare the level of plasmatic biomarkers of vascular risk in patients with and without exudative age-related macular degeneration (ARMD) and to relate it to vascular resistance alterations in the ophthalmic artery (OA), central retinal artery (CRA), posterior temporal ciliary artery (PTCA), and posterior nasal ciliary artery (PNCA). Methods: Color Doppler imaging of the OA, CRA, PTCA, and PNCA was performed in 30 eyes of 30 cataract patients (control group) as well as in 30 eyes of 30 patients with naive exudative ARMD (study group), measuring the peak systolic velocity, end-diastolic velocity (EDV), and Pourcelot resistive index (RI). Likewise, in both groups, a blood test was performed to determine the plasmatic levels of homocysteine, C-reactive protein (CRP), B12 vitamin, and folic acid. Results: A positive and significant correlation was found between the level of CRP and RI of the OA in the ARMD group (r = 0.498, P = 0.005), with an increased RI in all arteries compared to controls, although differences only reached statistical significance for the PTCA (P = 0.035). Likewise, a significantly lower EDV for the CRA was found in ARMD eyes compared to controls (P = 0.041). In the study group, significantly higher plasmatic levels of homocysteine (P = 0.042) and CRP (P = 0.046) were found. In contrast, no significant differences were found between groups in the levels of folic acid (P = 0.265) and B12 vitamin (P = 0.520). Conclusion: The decrease of the choroidal perfusion related to hyperhomocysteinemia, and increase in the CRP plasmatic levels may play an etiological role on the exudative ARMD. This should be investigated in future studies with larger samples of patients.en_US
dc.identifier.affiliationsDepartment of Ophthalmology, Marina Baixa Hospital, Villajoyosa, Spainen_US
dc.identifier.affiliationsUniversity of Castilla La Mancha, Spainen_US
dc.identifier.affiliationsCentre of Operative Research, Miguel Hernández University, Elche, Spainen_US
dc.identifier.affiliationsDepartment of Optics, Pharmacology and Anatomy, University of Alicante, Alicante, Spainen_US
dc.identifier.citationRodrigo F, Ruiz-Moreno JM, García JB, Torregrosa ME, Segura JV, Piñero DP. Color Doppler imaging of the retrobulbar circulation and plasmatic biomarkers of vascular risk in age-related macular degeneration: A pilot study. Indian Journal of Ophthalmology. 2018 Jan; 66(1): 89-93en_US
dc.identifier.issn0301-4738
dc.identifier.issn1998-3689
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/196542
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber1en_US
dc.relation.volume66en_US
dc.source.urihttps://dx.doi.org/10.4103/ijo.IJO_488_17en_US
dc.subjectAge-related macular degenerationen_US
dc.subjectB12 vitaminen_US
dc.subjectcolor Doppler imagingen_US
dc.subjectexudative age-related macular degenerationen_US
dc.subjectfolic aciden_US
dc.subjecthomocysteineen_US
dc.titleColor Doppler imaging of the retrobulbar circulation and plasmatic biomarkers of vascular risk in age-related macular degeneration: A pilot studyen_US
dc.typeJournal Articleen_US
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