Factors affecting the epithelial integrity of human donor corneas

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dc.contributor.authorKaur, Amanjoten_US
dc.contributor.authorMohamed, Ashiken_US
dc.contributor.authorPriyadarshini, Smruti Ren_US
dc.contributor.authorMohanty, Amritaen_US
dc.contributor.authorSahu, Srikant Ken_US
dc.contributor.authorDas, Sujataen_US
dc.date.accessioned2023-08-25T06:35:49Z
dc.date.available2023-08-25T06:35:49Z
dc.date.issued2023-01
dc.description.abstractPurpose: To evaluate various factors affecting the integrity of human donor corneal epithelium. Methods: Donor corneal buttons were evaluated for epithelial defect (ED) and exposure. The slit?lamp photographs were taken on day 01, and the data such as age and gender of the donor, cause of death, refrigeration of cadavers, death?to?preservation time (DPT), experience of technician, and distance from site of collection to eye bank were collected. Results: A total of 100 consecutive corneal buttons belonging to 56 donors were evaluated. The median age of donors was 50 years. Males constituted 45 (80.4%). The mean DPT was 9.7 ± 5.3 hours. After death, 34 donors (60.7%) were refrigerated before the collection/retrieval. Most of the corneas (80%) were recovered by technicians having an experience of 0–5 years. Thirty?one donors (55.3%) were located at 1–50 km from the eye bank. The mean area of exposure was 15 ± 4.3 mm2. The mean area of ED was 28.7 ± 5.9 mm2. ED was significantly associated with refrigeration of cadavers and longer DPT. On multivariate analysis, only DPT was found to be significantly associated (P = 0.006; odds ratio [OR] = 1.54 ± 0.24) with the presence of ED. After transplantation, only two corneas had persistent epithelial defects and were treated successfully using various interventions. Conclusion: Integrity of donor corneal epithelium is mainly influenced by the refrigeration of cadavers and DPT.en_US
dc.identifier.affiliationsCornea and Anterior Segment Service, L. V. Prasad Eye Institute, Bhubaneswar, Odisha, Indiaen_US
dc.identifier.affiliationsDepartment of Ophthalmic Biophysics, L. V. Prasad Eye Institute, Hyderabad, Telangana, Indiaen_US
dc.identifier.citationKaur Amanjot, Mohamed Ashik, Priyadarshini Smruti R, Mohanty Amrita, Sahu Srikant K, Das Sujata. Factors affecting the epithelial integrity of human donor corneas. Indian Journal of Ophthalmology. 2023 Jan; 71(1): 91-94en_US
dc.identifier.issn1998-3689
dc.identifier.issn0301-4738
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/224818
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber1en_US
dc.relation.volume71en_US
dc.source.urihttps://doi.org/10.4103/ijo.IJO_1470_22en_US
dc.subjectCorneal epitheliumen_US
dc.subjectdonor corneaen_US
dc.subjectMcCarey–Kaufman mediaen_US
dc.titleFactors affecting the epithelial integrity of human donor corneasen_US
dc.typeJournal Articleen_US
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