Antibiotic Susceptibility, Carrier State and Predictors of Outcome of Staphylococcus aureus Infections in Hospitalized Children

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dc.contributor.authorKaur, Kiranpreeten_US
dc.contributor.authorKhalil, Sumairaen_US
dc.contributor.authorSingh, NPen_US
dc.contributor.authorDewan, Poojaen_US
dc.contributor.authorGupta, Piyushen_US
dc.contributor.authorShah, Dheerajen_US
dc.date.accessioned2023-08-25T06:40:00Z
dc.date.available2023-08-25T06:40:00Z
dc.date.issued2023-01
dc.description.abstractObjectives: To evaluate the antibiotic resistance pattern, clinical profile and predictors for adverse outcomes in children hospitalized due to staphylococcal infection; and the frequency of nasal and axillary carrier states in these children. Methods: This descriptive study enrolled 100 symptomatic children (aged 1 month - 12 years) in whom S. aureus was isolated from cultures of blood, pus or cerebrospinal fluid. All samples were processed as per the Clinical and Laboratory Standards Institute (CLSI) standards. Antimicrobial susceptibility was tested using disc diffusion method; minimum inhibitory concentration (MIC) for vancomycin was measured using E strips. Predictors for poor recovery were determined by univariate and multivariable logistic regression analysis. Results: Skin and soft tissue infections were the most common (47%) followed by respiratory infections (37%). Methicillin-resistant Staphylococcus aureus (MRSA) was detected in 62%, out of which 63% (39/62) were multi-drug resistant. Carrier state was present in 49% (93% MRSA); 80% were axillary carriers. High MIC (>1 µg/mL) for vancomycin was seen in 65% of patients, and was the only factor associated with poor recovery [aOR (95%CI) 5.3 (1.6,18.5); P=0.008] on multivariable logistic regression analysis. Conclusion: MRSA is the predominant strain in severe staphylococcal infections requiring hospitalization, and majority of them are multidrug resistant. High MIC to vancomycin among S. aureus is an emerging concern.en_US
dc.identifier.affiliationsDepartments of Pediatrics anden_US
dc.identifier.affiliationsMicrobiology, University College of Medical Sciences (University of Delhi) and GTB Hospital, Delhien_US
dc.identifier.citationKaur Kiranpreet, Khalil Sumaira, Singh NP, Dewan Pooja, Gupta Piyush, Shah Dheeraj. Antibiotic Susceptibility, Carrier State and Predictors of Outcome of Staphylococcus aureus Infections in Hospitalized Children. Indian Pediatrics. 2023 Jan; 60(1): 49-53en_US
dc.identifier.issn0079-6061
dc.identifier.issn0974-7559
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/225447
dc.languageenen_US
dc.publisherIndian Academy of Pediatricsen_US
dc.relation.issuenumber1en_US
dc.relation.volume60en_US
dc.source.urihttps://indianpediatrics.net/jan2023/49.pdfen_US
dc.subjectAntimicrobial resistanceen_US
dc.subjectMethicillin-resistanceen_US
dc.subjectTreatment failureen_US
dc.titleAntibiotic Susceptibility, Carrier State and Predictors of Outcome of Staphylococcus aureus Infections in Hospitalized Childrenen_US
dc.typeJournal Articleen_US
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