Efficacy and Safety of Conventional Synthetic Disease Modifying Anti-Rheumatic Drugs (csDMARDs) on the treatment of Rheumatoid Arthritis
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Date
2024-12
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Department of Community Medicine, Institute of Medical Sciences, Banaras Hindu University
Abstract
Introduction: Rheumatoid arthritis is a systemic disease that can induce a wide range of extra-articular symptoms. CsDMARDs–methotrexate, hydrochloroquine, leflunomide, and sulfasalazine are a few beneficial remedies for RA. DMARDs are a mainstay in the management of rheumatoid arthritis. Objective-To assess the efficacy of Conventional Synthetic DMARDson the treatment of Rheumatoid Arthritis. Methodology: A total 36 patients of Rheumatoid Arthritis fulfilling the inclusion criteria and having symptoms of RA were enrolled for this Interventional study from OPDof Department of Medicine, SS Hospital, Institute of Medical Sciences, BHU, Varanasi and were followed for three months.After the completion of the study, 32 patients completed all 3 follow-ups. Result: DMARDs has significantly improved the RA factor, Anti CCP, CRP and ESR values, as median values of these diagnostic tests have reduced over time(RA factor-27.12 to 16.24, Anti CCP-28.26 to 18.86, CRP –7.65 to 4.23 and ESR-34.50 to 23.50). After 3 months treatment with synthetic DMARDs, the mean SGOT, SGPT and Urea level decreased significantly from 36.43 ± 12.92 to 31.93 ± 10.92, 38.74 ± 12.15 to 34.01 ± 10.59 and 39.14 ± 12.34 to 34.51 ± 10.44 respectively. DMARDs was also effective in reducing the pain (joint pain, low back pain and neck pain),as median values of joint pain, low back pain and neck pain have reduced over time(Joint pain-6 to 3, Low Back Pain-6 to 2 and Neck Pain-4.5 to 1). Adverse effects were observed in more than 30% of patients Discussion: The study showed that DMARDs was effective and safe for the treatment of Rheumatoid Arthritis according to the biochemical and clinical pain score finding over -90 day follow up. A long term follows up and histological examination, invasive or non –invasive, is required to give conclusive report.
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Keywords
Rheumatoid Arthritis, Efficacy, DMARDs, Safety
Citation
Kumar S, Pandey A, Prasad R, Singh AK, Yadav P.. Efficacy and Safety of Conventional Synthetic Disease Modifying Anti-Rheumatic Drugs (csDMARDs) on the treatment of Rheumatoid Arthritis . Indian Journal of Preventive & Social Medicine. 2024 Dec; 55(4): 259-265