Evaluating erectile dysfunction: oral sildenafil versus intracavernosal injection of papaverine.

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dc.contributor.authorViswaroop, Bobbyen_US
dc.contributor.authorB, Antonisamyen_US
dc.contributor.authorGopalakrishnan, Ganeshen_US
dc.date.accessioned2005-11-18en_US
dc.date.accessioned2009-06-03T07:27:07Z
dc.date.available2005-11-18en_US
dc.date.available2009-06-03T07:27:07Z
dc.date.issued2005-11-18en_US
dc.description.abstractBACKGROUND: Intracavernosal injection of vasoactive drugs is an established method of evaluating erectile dysfunction. However, it is invasive and may be associated with pain and priapism. We investigated the use of oral sildenafil as a possible substitute for intracavernosal agents. METHODS: Men with erectile dysfunction were randomized into two groups of 25 each. One group of 25 men received injection papaverine initially followed by oral sildenafil, and another 25 received oral sildenafil followed by injection papaverine. Genital self-stimulation was used in both the groups. Penile length and circumference as well as angle of erection, before and after each medication, were recorded. Two days later, the intervention arms were crossed over. Subjective responses were obtained. The effect of medication on each outcome variable was studied by using analysis of variance models in relation to patient, period and medication. RESULTS: There was statistically significant improvement from the baseline value in both the arms, i.e injection papaverine and oral sildenafil (p<0.001, p<0.001, respectively) for both penile length and circumference. No significant difference was observed between the two medications in the outcome measures. CONCLCUSION: Oral sildenafil was as effective as injection papaverine in evaluating erectile dysfunction.en_US
dc.description.affiliationChristian Medical College, Dr Ida Scudder Road, Vellore 632004, Tamil Nadu, India.en_US
dc.identifier.citationViswaroop B, B A, Gopalakrishnan G. Evaluating erectile dysfunction: oral sildenafil versus intracavernosal injection of papaverine. National Medical Journal of India. 2005 Nov-Dec; 18(6): 299-301en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/119726
dc.language.isoengen_US
dc.source.urihttps://www.nmji.inen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAnalysis of Varianceen_US
dc.subject.meshCross-Over Studiesen_US
dc.subject.meshErectile Dysfunction --drug therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshInjectionsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPapaverine --administration & dosageen_US
dc.subject.meshPhosphodiesterase Inhibitors --administration & dosageen_US
dc.subject.meshPiperazines --administration & dosageen_US
dc.subject.meshPurinesen_US
dc.subject.meshSulfonesen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleEvaluating erectile dysfunction: oral sildenafil versus intracavernosal injection of papaverine.en_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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