Ophthalmic complications and management of Stevens-Johnson syndrome at a tertiary eye care centre in south India.

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dc.contributor.authorKompella, Viswanadh Ben_US
dc.contributor.authorSangwan, Virender Sen_US
dc.contributor.authorBansal, Aashish Ken_US
dc.contributor.authorGarg, Prashanten_US
dc.contributor.authorAasuri, Murali Ken_US
dc.contributor.authorRao, Gullapalli Nen_US
dc.date.accessioned2002-12-21en_US
dc.date.accessioned2009-05-29T09:49:33Z
dc.date.available2002-12-21en_US
dc.date.available2009-05-29T09:49:33Z
dc.date.issued2002-12-21en_US
dc.description.abstractPURPOSE: To review the possible aetiological factors, ocular complications and their management in patients of Stevens-Johnson syndrome with ocular involvement, seen at a tertiary eye care centre. METHODS: We retrospectively reviewed the medical records of patients with Stevens-Johnson syndrome seen between 1987-1998 at L V Prasad Eye Institute. The demographic and possible aetiological factors data causing Stevens-Johnson syndrome were collected. The details of the ocular examination and treatment were collected and examined to determine the pattern of presentation, complications, treatment response and outcome. RESULTS: A total of 95 patients, 40 males (42.10%) and 55 females (57.89%), were identified during the 11-year period. A majority of the patients (n = 53; 55.78%) were between 20 and 40 years of age. All patients had bilateral involvement and most (n = 93; 97.89%) had bilateral symmetrical presentation. The duration from the onset of symptoms to the time of presentation at the institute varied from 6 days to 18 years with most patients presenting after one year (n = 39; 41.05%). The most commonly identified possible causative factor was drugs (n = 55; 51.89%). No definitive cause was identified in 37 (38.94%) patients, and 3 (3.15%) patients had a history of viral fever preceding the onset of Stevens-Johnson syndrome. The best corrected visual acuity at initial presentation was 6/12 or better in 32 (33.68%) patients. Lid abnormalities were observed in 87 (91.51%) patients, conjunctival abnormalities in 92 (96.84%) and corneal complications in 93 (97.89%). All patients were managed medically and 26 (27.36%) patients underwent surgery. CONCLUSION: Stevens-Johnson syndrome remains an important cause of severe visual loss and ocular morbidity, both of which significantly affect the quality of life. Not many medical or surgical options are available even in tertiary eye-care centres. Future advances in immune modulation techniques may prevent many of the sequelae that continue to occur despite the best possible medical care.en_US
dc.description.affiliationCornea Service, L V Prasad Eye Institute, L V Prasad Marg, Banjara Hills, Hyderabad-500 034, India.en_US
dc.identifier.citationKompella VB, Sangwan VS, Bansal AK, Garg P, Aasuri MK, Rao GN. Ophthalmic complications and management of Stevens-Johnson syndrome at a tertiary eye care centre in south India. Indian Journal of Ophthalmology. 2002 Dec; 50(4): 283-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/72016
dc.language.isoengen_US
dc.source.urihttps://www.ijo.inen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshEye Diseases --etiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHospitals, Universityen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOphthalmologic Surgical Proceduresen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshStevens-Johnson Syndrome --complicationsen_US
dc.subject.meshTreatment Outcomeen_US
dc.subject.meshVisual Acuityen_US
dc.titleOphthalmic complications and management of Stevens-Johnson syndrome at a tertiary eye care centre in south India.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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