Bone marrow aspirations in Ewing sarcomas: Are they still necessary? A single-center retrospective analysis and review of the literature

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dc.contributor.authorBreitegger, Bernadetteen_US
dc.contributor.authorHolzer, Lukas Aen_US
dc.contributor.authorBeham-Schmid, Christineen_US
dc.contributor.authorUrban, Christianen_US
dc.contributor.authorLiegl-Atzwanger, Bernadetteen_US
dc.contributor.authorLeithner, Andreasen_US
dc.date.accessioned2020-11-18T10:08:09Z
dc.date.available2020-11-18T10:08:09Z
dc.date.issued2020-09
dc.description.abstractBackground and Objectives: Currently, one of the most useful prognostic indicators in Ewing sarcomas (ES) is the presence of metastatic disease at diagnosis. According to various clinical guidelines, the assessment of bone marrow (BM) metastases, using light microscopy examination of bone marrow aspirates and biopsies (BMAB) is mandatory. However, the prognostic value of BM positivity is discussed controversially. Therefore, the primary aim of this study was to retrospectively review BM samples from patients with ES. Materials and Methods: This retrospective single centre study included 31 patients that were newly diagnosed with ES between 2000 and 2014. Twenty-seven patients had skeletal ES and in 4 patients the tumour was localized in the soft tissue only. Metastases at diagnosis were present in 5 out of 31 patients. BM samples were morphologically and immunohistochemically searched and screened for the presence or absence of BM metastases. Furthermore, in 15 of the 31 patients BM samples were still available and were reanalysed, using nested-polymerase chain reaction. Results: All BM samples of our 31 ES patients, including the 5 metastatic patients, were, morphologically and immunohistochemically tested negative for tumour cell appearance. The nested-PCR results were also negative in all of our 15 retested patients, including two patients with metastatic disease. Conclusions: Based on our results and on the contradictory results reported in the literature we recommend a re-evaluation of the necessity and the prognostic value of BMAB in the initial staging process of newly diagnosed ES patientsen_US
dc.identifier.affiliationsDepartment of Orthopaedic Surgery, Medical University of Graz, Graz, Austriaen_US
dc.identifier.affiliationsDepartment of Orthopaedic Surgery, Medical University of Graz, Graz, Austriaen_US
dc.identifier.affiliations|Department of Pediatrics, Division of Pediatric Haematology and Oncology, Medical University of Graz, Graz, Austriaen_US
dc.identifier.affiliationsDepartment of Pathology, Medical University of Graz, Graz, Austriaen_US
dc.identifier.affiliationsDepartment of Orthopaedic Surgery, Medical University of Graz, Graz, Austriaen_US
dc.identifier.affiliationsDepartment of Orthopaedic Surgery, Medical University of Graz, Graz, Austriaen_US
dc.identifier.citationBreitegger Bernadette, Holzer Lukas A, Beham-Schmid Christine, Urban Christian, Liegl-Atzwanger Bernadette, Leithner Andreas. Bone marrow aspirations in Ewing sarcomas: Are they still necessary? A single-center retrospective analysis and review of the literature. Journal of Cancer Research and Therapeutics. 2020 Sep; 16(4): 713-717en_US
dc.identifier.issn0973-1482
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/213691
dc.languageenen_US
dc.publisherWolters Kluwer India Pvt. Ltd.en_US
dc.relation.issuenumber4en_US
dc.relation.volume16en_US
dc.source.urihttps://dx.doi.org//10.4103/jcrt.JCRT_941_16en_US
dc.subjectBone marrow aspiration/biopsyen_US
dc.subjectbone marrow metastasesen_US
dc.subjectEwing sarcomaen_US
dc.titleBone marrow aspirations in Ewing sarcomas: Are they still necessary? A single-center retrospective analysis and review of the literatureen_US
dc.typeJournal Articleen_US
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