Evaluating in vitro antioxidant activity and GC-MS analysis of Scoparia dulcis Linn (Scrophulariacae).

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dc.contributor.authorWankhar, Wankupar
dc.contributor.authorSrinivasan, Sakthivel
dc.contributor.authorRajan, Ravindran
dc.contributor.authorRathinasamy, Sheeladevi
dc.date.accessioned2015-11-24T10:36:14Z
dc.date.available2015-11-24T10:36:14Z
dc.date.issued2015-07
dc.description.abstractFree radical scavenging activity was observed in both the methanol extract (M.E) and aqueous extract (A.E) of Scoparia dulcis respectively. In this study significant free radical scavenging activity was determined by evaluating the inhibition concentration (IC50) in each test. In 2, 2-diphenyl-1-picrylhydrazyl (DPPH) model the extract displayed potential free radicals scavenging activity with IC50 of M.E is 311.13µg/mL and A.E is 441.96μg/mL. Nitric oxide model displayed IC50 of 293.77µg/mL in M.E and 434.93µg/mL in A.E. While superoxide ion model showed IC50 of 281.02 µg/mL and 440.14µg/mL respectively for both methanol and aqueous extract when compared to standard ascorbic acid. The presence of phenol, flavonoid and total antioxidant in both the extract justifies the antioxidant potential of the plant which brings about its free radicals scavenging potential. GC-MS analysis showed the presence of 6 different phytochemicals with (Z)-7-Hexadecenyl acetate found to be the compound with maximum peak percentage 51.51% in M.E and β-Cyclocitral with 43.90% in A.E respectively. Thus we conclude that the antioxidant activities may be due to the cumulative effect of the phytochemicals present in the plant which genuinely designate them as free radical scavenger.en_US
dc.identifier.citationWankhar Wankupar, Srinivasan Sakthivel, Rajan Ravindran, Rathinasamy Sheeladevi. Evaluating in vitro antioxidant activity and GC-MS analysis of Scoparia dulcis Linn (Scrophulariacae). Journal of Applied Pharmaceutical Science. 2015 July; 5(7): 29-34.en_US
dc.identifier.issn2231-3354
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/166205
dc.language.isoenen_US
dc.source.urihttps://www.japsonline.com/abstract.php?article_id=1550en_US
dc.subjectScoparia dulcisen_US
dc.subjectantioxidanten_US
dc.subjectfree radicalsen_US
dc.subjectphytochemicalen_US
dc.subjectGas chromatography–mass spectrometry (GC-MS)en_US
dc.titleEvaluating in vitro antioxidant activity and GC-MS analysis of Scoparia dulcis Linn (Scrophulariacae).en_US
dc.typeArticleen_US
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