Field assessment of recombinant Schistosoma japonicum 26 kDa glutathione S-transferase in Chinese water buffaloes.

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dc.contributor.authorHe, Y Ken_US
dc.contributor.authorLiu, S Xen_US
dc.contributor.authorZhang, X Yen_US
dc.contributor.authorSong, G Cen_US
dc.contributor.authorLuo, X Sen_US
dc.contributor.authorLi, Y Sen_US
dc.contributor.authorXu, Y Xen_US
dc.contributor.authorYu, X Len_US
dc.contributor.authorLi, Yen_US
dc.contributor.authorHou, X Yen_US
dc.contributor.authorMcManus, D Pen_US
dc.date.accessioned2009-05-27T16:42:45Z
dc.date.available2009-05-27T16:42:45Z
dc.date.issued2003-09-30en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractWe have shown previously that anti-fecundity immunity can be induced experimentally against recombinant 26 kDa glutathione S-transferase (reSjc26GST) in Chinese water buffaloes (Bos buffelus), important reservoir hosts for Schistosoma japonicum in China. In the field study described here, we immunized buffaloes with reSjc26GST to induce protective immunity against S. japonicum and to evaluate its effectiveness in controlling schistosomiasis japonica. We selected two villages as test and control groups in inside-embankment areas endemic for schistosomiasis japonica. The buffaloes in the test village were vaccinated with reSjc26GST, whereas those in the control village were not. The indicators of the effect of the vaccine included the generation of specific IgG antibodies in the vaccinated buffaloes, changes in the prevalence and infection intensity in buffaloes and village children, changes in the density of infected snails, and changes in the infectivity of water bodies (assessed by sentinel mice) in transmission areas adjacent to both villages. Twenty months after vaccination, the infection rate of buffaloes in the test village was decreased by 60.4% (from an initial prevalence of 13.5% to 5.4%), and 67.9% when compared with that in the control village (initial prevalence of 16.7%). However, the infection rate in village children remained unchanged. The density of infected snails decreased by 71.4%, from 0.0049/0.11 m2 to 0.0014/0.11m2 in the high transmission area outside the embankment in the test village. There was no change in the infectivity of the water body transmission areas between the test and control villages. The levels of specific antibodies to reSjc26GST showed a continuous increase after vaccination. These results indicate that protective immunity was induced and maintained in buffaloes after vaccination with reSjc26GST. The vaccine could thus play a significant role in reducing S. japonicum transmission caused by water buffaloes in the Lake region of China.en_US
dc.description.affiliationHunan Institute of Parasitic Diseases and WHO Collaborating Center for Research and Control on Schistosomiasis in the Lake Region, Hunan.en_US
dc.identifier.citationHe YK, Liu SX, Zhang XY, Song GC, Luo XS, Li YS, Xu YX, Yu XL, Li Y, Hou XY, McManus DP. Field assessment of recombinant Schistosoma japonicum 26 kDa glutathione S-transferase in Chinese water buffaloes. The Southeast Asian Journal of Tropical Medicine and Public Health. 2003 Sep; 34(3): 473-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/35839
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/2003_34_3/02-3070.pdfen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibodies, Helminth --blooden_US
dc.subject.meshAntigens, Helminth --immunologyen_US
dc.subject.meshBuffaloes --parasitologyen_US
dc.subject.meshChina --epidemiologyen_US
dc.subject.meshDisease Reservoirsen_US
dc.subject.meshFertility --immunologyen_US
dc.subject.meshGlutathione Transferase --immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshRecombinant Proteins --immunologyen_US
dc.subject.meshSchistosoma japonicum --immunologyen_US
dc.subject.meshSchistosomiasis japonica --epidemiologyen_US
dc.subject.meshSnails --parasitologyen_US
dc.subject.meshVaccination --veterinaryen_US
dc.subject.meshVaccines, Syntheticen_US
dc.subject.meshWater --parasitologyen_US
dc.titleField assessment of recombinant Schistosoma japonicum 26 kDa glutathione S-transferase in Chinese water buffaloes.en_US
dc.typeJournal Articleen_US
dc.typeMulticenter Studyen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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