Cortical activation during finger tapping in thyroid dysfunction: a functional magnetic resonance imaging study.

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dc.contributor.authorKhushu, Sen_US
dc.contributor.authorKumaran, S Senthilen_US
dc.contributor.authorSekhri, Ten_US
dc.contributor.authorTripathi, R Pen_US
dc.contributor.authorJain, P Cen_US
dc.contributor.authorJain, Ven_US
dc.date.accessioned2006-12-16en_US
dc.date.accessioned2009-06-01T14:28:07Z
dc.date.available2006-12-16en_US
dc.date.available2009-06-01T14:28:07Z
dc.date.issued2006-12-16en_US
dc.description.abstractThyroid dysfunction is associated with attention deficit and impairment of the motor system (muscle weakness and fatigue). This paper investigates possible motor function deficit in thyroid patients,compared to the controls. Functional MRI studies (fMRI)were carried out in five hypo and five hyperthyroid patients and six healthy volunteers. Whole brain imaging was performed using echo planar imaging (EPI)technique, on a 1.5T whole body MR system (Siemens Magnetom Vision). The task paradigm consisted of 8 cycles of active and reference phases of 6 measurements each, with right index finger tapping at a rate of 120 taps/min. Post-processing was performed using statistical parametric mapping on a voxel-by-voxel basis using SPM99. Clusters of activation were found in the contralateral hemisphere in primary somatomotor area (M1), supplementary motor area (SMA), somatosensory,auditory receptive and integration areas, inferior temporal lobe, thalamus and cerebellum. Increased clusters of activation were observed in M1 in thyroid subjects as compared to controls and with bilateral activation of the primary motor cortex in two hyperthyroid patients. The results are explained in terms of increased functional demands in thyroid patients compared to volunteers for the execution of the same task.en_US
dc.description.affiliationNMR Research Centre, Institute of Nuclear Medicine and Allied Sciences, Brig.S K Majumdar Road, Delhi 110 054, India. skhushu@yahoo.comen_US
dc.identifier.citationKhushu S, Kumaran SS, Sekhri T, Tripathi RP, Jain PC, Jain V. Cortical activation during finger tapping in thyroid dysfunction: a functional magnetic resonance imaging study. Journal of Biosciences. 2006 Dec; 31(5): 543-50en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/110849
dc.language.isoengen_US
dc.source.urihttps://www.ias.ac.in/jbiosci/index.htmlen_US
dc.subject.meshAdulten_US
dc.subject.meshBrain Mappingen_US
dc.subject.meshFingers --physiopathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshHyperthyroidism --physiopathologyen_US
dc.subject.meshHypothyroidism --physiopathologyen_US
dc.subject.meshMagnetic Resonance Imagingen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMotor Activityen_US
dc.subject.meshMotor Cortex --physiopathologyen_US
dc.titleCortical activation during finger tapping in thyroid dysfunction: a functional magnetic resonance imaging study.en_US
dc.typeJournal Articleen_US
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