Selectively enhanced sensitivity of bronchoalveolar lavage fluid (BALF) mast cells to IgE dependent stimulation in mild asthmatics.

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dc.contributor.authorXie, Huaen_US
dc.contributor.authorHe, Shaohengen_US
dc.contributor.authorChen, Pingen_US
dc.date.accessioned2009-05-27T17:08:22Z
dc.date.available2009-05-27T17:08:22Z
dc.date.issued2003-06-25en_US
dc.descriptionPublished by the Allergy and Immunology Society of Thailand.en_US
dc.description.abstractThe aim of this study is to investigate the histamine-releasing ability of mast cells from asthmatic bronchoalveolar lavage fluid (BALF). Following the measurement of the forced expiratory volume at the first second (FEV1), 29 mild asthmatics were included in the study and were subjected to fibreoptic bronchoscopy. The cells recovered from the BALF were challenged with anti-IgE, calcium ionophore A23187 (CI) or adenosine, and the released histamine was measured with an enzyme-linked chromogenic assay. Enzymatically dispersed mast cells from human lung or colon tissues were employed as control groups. The results showed that mast cells from BALF were at least 100 fold more sensitive to anti-IgE than those from lung or colon tissues. However, there was little difference between mast cells from BALF, lung or colon tissues in response to CI. Adenosine failed to stimulate histamine release from BALF mast cells. In conclusion, asthmatic BALF mast cells are much more sensitive to IgE-dependent stimulation than the non-IgE-dependent ones, indicating that mast cells may play a role in the pathogenesis of asthma.en_US
dc.description.affiliationAllergy and Inflammation Research Institute, the Shantou University Medical College, Shantou, PR China.en_US
dc.identifier.citationXie H, He S, Chen P. Selectively enhanced sensitivity of bronchoalveolar lavage fluid (BALF) mast cells to IgE dependent stimulation in mild asthmatics. Asian Pacific Journal of Allergy and Immunology. 2003 Jun; 21(2): 83-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/36536
dc.language.isoengen_US
dc.subject.meshAdenosine --administration & dosageen_US
dc.subject.meshAdulten_US
dc.subject.meshAntibodies, Anti-Idiotypic --administration & dosageen_US
dc.subject.meshAsthma --immunologyen_US
dc.subject.meshBronchoalveolar Lavage Fluid --cytologyen_US
dc.subject.meshBronchoscopesen_US
dc.subject.meshCalcimycin --administration & dosageen_US
dc.subject.meshColon --cytologyen_US
dc.subject.meshDose-Response Relationship, Immunologicen_US
dc.subject.meshFemaleen_US
dc.subject.meshForced Expiratory Volume --drug effectsen_US
dc.subject.meshHistamine Release --drug effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin E --drug effectsen_US
dc.subject.meshIonophores --administration & dosageen_US
dc.subject.meshLung --cytologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMast Cells --drug effectsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSensitivity and Specificityen_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshVasodilator Agents --administration & dosageen_US
dc.titleSelectively enhanced sensitivity of bronchoalveolar lavage fluid (BALF) mast cells to IgE dependent stimulation in mild asthmatics.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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