Increased brainstem angiotensin-I levels in chronic 2 KIC hypertensive rats.

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dc.contributor.authorLall, S Ben_US
dc.contributor.authorMenon, S Men_US
dc.contributor.authorKarmarkar, M Gen_US
dc.contributor.authorSiddiqui, H Hen_US
dc.contributor.authorSeth, S Den_US
dc.date.accessioned1990-02-01en_US
dc.date.accessioned2009-05-27T06:29:04Z
dc.date.available1990-02-01en_US
dc.date.available2009-05-27T06:29:04Z
dc.date.issued1990-02-01en_US
dc.description.abstractA study was undertaken on the role of brainstem renin-angiotensin system in maintenance of hypertension in chronic renovascular hypertensive rats. Hypertension was induced by unilateral renal artery clamping, while the contralateral kidney was left intact (2 KIC). Blood pressure (BP), plasma renin activity (PRA) and brainstem angiotensin (ang-I) levels were measured after 24 days, in hypertensive and sham-operated animals. In separate subgroups of these animals, the effect of intracerebroventricular administration of captopril on the parameters listed was studied. The results showed high ang-I levels in 2 KIC rats as compared to controls (P less than 0.05). Captopril administration (500 micrograms/50 microliters icv) caused a fall in BP and increase in brainstem ang-I levels (P less than 0.01). In control animals, however, captopril produced a rise in BP without any significant change in brainstem ang-I levels. Peripheral plasma renin activity was normal, despite significant sodium retention in 2 KIC rats. The results are suggestive of activation of brainstem renin-angiotensin system (RAS) in chronic 2 KIC hypertension.en_US
dc.description.affiliationDepartment of Pharmacology, India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationLall SB, Menon SM, Karmarkar MG, Siddiqui HH, Seth SD. Increased brainstem angiotensin-I levels in chronic 2 KIC hypertensive rats. Indian Journal of Medical Research. 1990 Feb; 92(): 43-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/16458
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAngiotensin I --metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBrain Stem --metabolismen_US
dc.subject.meshCaptopril --pharmacologyen_US
dc.subject.meshHypertension, Renovascular --metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.titleIncreased brainstem angiotensin-I levels in chronic 2 KIC hypertensive rats.en_US
dc.typeJournal Articleen_US
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