Detection rate of prostate cancer using prostate specific antigen in patients presenting with lower urinary tract symptoms: a retrospective study.

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dc.contributor.authorChavan, P Ren_US
dc.contributor.authorChavan, S Ven_US
dc.contributor.authorChavan, N Ren_US
dc.contributor.authorTrivedi, V Den_US
dc.date.accessioned2009-01-27en_US
dc.date.accessioned2009-06-02T13:13:02Z
dc.date.available2009-01-27en_US
dc.date.available2009-06-02T13:13:02Z
dc.date.issued2009-01-27en_US
dc.description.abstractBACKGROUND: Need for undertaking prostate biopsies for detection of prostate cancer is often decided on the basis of serum levels of prostate specific antigen (PSA). AIM: To evaluate the case detection rate of prostate cancer among patients presenting with lower urinary tract symptoms (LUTS) on the basis of PSA levels and to assess the scope of prostate biopsy in these patients. SETTING AND DESIGN: A retrospective study from a tertiary care center. MATERIALS AND METHODS: The clinical and histopathological data of 922 patients presenting with LUTS in the last five years was obtained from the medical record section. They had been screened for prostate cancer using PSA and /or digital rectal examination examination followed by confirmation with prostate biopsy. STATISTICAL ANALYSIS USED: Detection rate and receiver operating characteristic curve were performed using SPSS 16 and Medcalc softwares. RESULTS: The detection rate of prostate cancer according to the PSA levels was 0.6%, 2.3%, 2.5%, 34.1% and 54.9% in the PSA range of 0-4, 4-10, 10-20, 20-50 and> 50 ng/ml, respectively. Maximum prostate cancer cases were detected beyond a PSA value of 20 ng/ml whereas no significant difference in the detection rate was observed in the PSA range of 0-4, 4-10 and 10-20 ng/ml. CONCLUSION: A low detection rate of prostate cancer observed in the PSA range of 4-20 ng/ml in LUTS patients indicates the need for use of higher cutoff values of PSA in such cases. Therefore we recommend a cutoff of 20 ng/ml of PSA for evaluation of detection rate of prostate cancer among patients presenting with LUTS.en_US
dc.description.affiliationDepartment of Biochemistry, Lokmanya Tilak Municipal Medical College and Lokmanya Tilak Municipal General Hospital, Sion, Mumbai-400 022, India. padmachavan@rediffmail.comen_US
dc.identifier.citationChavan PR, Chavan SV, Chavan NR, Trivedi VD. Detection rate of prostate cancer using prostate specific antigen in patients presenting with lower urinary tract symptoms: a retrospective study. Journal of Postgraduate Medicine. 2009 Jan-Mar; 55(1): 17-21en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/117444
dc.language.isoengen_US
dc.source.urihttps://www.jpgmonline.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshBiopsyen_US
dc.subject.meshDiagnosis, Differentialen_US
dc.subject.meshDigital Rectal Examinationen_US
dc.subject.meshEarly Detection of Canceren_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProstate-Specific Antigen --blooden_US
dc.subject.meshProstatic Neoplasms --blooden_US
dc.subject.meshProstatism --pathologyen_US
dc.subject.meshROC Curveen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshUrinary Tract Infections --complicationsen_US
dc.titleDetection rate of prostate cancer using prostate specific antigen in patients presenting with lower urinary tract symptoms: a retrospective study.en_US
dc.typeJournal Articleen_US
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