Effect of ramipril therapy on cognitive functions in cases of mild to moderate essential hypertension.

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dc.contributor.authorQureshi, Nasreenen_US
dc.contributor.authorBabbar, Rashmien_US
dc.date.accessioned2007-01-20en_US
dc.date.accessioned2009-06-01T05:07:48Z
dc.date.available2007-01-20en_US
dc.date.available2009-06-01T05:07:48Z
dc.date.issued2007-01-20en_US
dc.description.abstractSeveral studies have questioned the effect of hypertension on cognitive functions. Event related potentials (P300) have been used as a reliable and reproducible indicator of cognitive functions. In this non-randomized, open label study we investigated cognitive functions using event related potentials in newly diagnosed mild to moderate essential hypertensive patients and whether or not there was any effect of antihypertensive treatment with angiotensin converting enzyme inhibitor ramipril on the event related potentials. We selected twenty male patients of newly diagnosed mild to moderate essential hypertension by using ambulatory blood pressure monitoring who were previously untreated and compared their event related potentials with 10 normotensive controls. At the beginning of the study, the hypertensive group showed increased P300 and N2 wave latency as compared to the normotensive control subjects. After three months of Ramipril therapy at a dose of 5mg per day, there was a significant decrease in all the ambulatory blood pressure parameters and the mean P300 latency from the pretreatment values. But no significant change in the N2 latency was observed. Thus, treatment with Ramipril 5 mg daily for a period of three months can reverse some aspects of cognitive dysfunction associated with hypertension.en_US
dc.description.affiliationDepartment of Physiology, Maulana Azad Medical College, New Delhi. drnasreen2003@yahoo.comen_US
dc.identifier.citationQureshi N, Babbar R. Effect of ramipril therapy on cognitive functions in cases of mild to moderate essential hypertension. Indian Journal of Physiology and Pharmacology. 2007 Jan-Mar; 51(1): 40-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/106374
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAngiotensin-Converting Enzyme Inhibitors --pharmacologyen_US
dc.subject.meshBlood Pressure --drug effectsen_US
dc.subject.meshBlood Pressure Monitoring, Ambulatory --methodsen_US
dc.subject.meshCircadian Rhythmen_US
dc.subject.meshCognition Disorders --complicationsen_US
dc.subject.meshEvent-Related Potentials, P300 --drug effectsen_US
dc.subject.meshEvoked Potentials, Auditory --drug effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension --complicationsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRamipril --therapeutic useen_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleEffect of ramipril therapy on cognitive functions in cases of mild to moderate essential hypertension.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
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