Changes in ocular surface after withdrawal of anti-glaucoma medications following non-penetrating deep sclerectomy

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dc.contributor.authorFuente-García, Carlotaen_US
dc.contributor.authorMuñoz-Negrete, Francisco Joséen_US
dc.contributor.authorde Dompablo, Elisabeten_US
dc.contributor.authorMoreno-Montañés, Javieren_US
dc.contributor.authorRebolleda, Gemaen_US
dc.date.accessioned2023-08-25T06:32:57Z
dc.date.available2023-08-25T06:32:57Z
dc.date.issued2022-05
dc.description.abstractPurpose: To analyze the ocular surface changes in eyes after the withdrawal of anti?glaucomatous drugs when non?penetrating deep sclerectomy (NPDS) is performed. Methods: Thirty?one patients (33 eyes) diagnosed with glaucoma that underwent NPDS were included in this prospective study. The control group included 33 eyes. Four variables were studied using Keratograph 5M (K5M): ocular hyperemia (OH), non?invasive tear film break?up time (NI?BUT), lower tear meniscus height (LTMH), and meibography. LTMH was also measured using the anterior segment module of a Spectralis Fourier?domain optical coherence tomography (FD?OCT) instrument. Moreover, an evaluation of corneal and conjunctival staining was performed. In the glaucoma group, five visits were carried out: pre?surgery, 1 week after surgery, and 1 month, 3 months, and 6 months after surgery. In control groups, examinations were performed in only one visit. In addition, patients were asked to answer two questionnaires: Ocular Surface Disease Index (OSDI) and National Eye Institute Visual Functioning Questionnaire (NEI VFQ?25) before and 6 months after surgery. Results: Before NPDS, eyes showed worse objective data than healthy control subjects (P ? 0.049). In this group, a significant improvement was observed in questionnaire responses (P < 0.001), LTMH?FD?OCT (P = 0.037), LTMH?K5M (P = 0.025), K5M?OH (P = 0.003), NI?BUT (P = 0.022), and conjunctival and corneal staining (P < 0.001). No significant differences were observed between groups in FD?OCT and K5M LTMH, NI?BUT, corneal?conjunctival staining, nor in the most OH sector values at 6 months (P ? 0.62). Conclusion: A significant improvement in the ocular surface was observed 6 months after NPDS, suggesting that the withdrawal of the topical anti?glaucomatous treatment had a beneficial effect on the subjectsen_US
dc.identifier.affiliationsOphthalmology Service, University Hospital Ramón y Cajal, Madrid, Spainen_US
dc.identifier.affiliationsSchool of Medicine and Health Science, University of Alcalá, Madrid, Spainen_US
dc.identifier.affiliationsRamon y Cajal Institute of Health Research (IRYCIS), Ophthalmology, Madrid, Spainen_US
dc.identifier.affiliationsDepartment of Ophthalmology, Clínica Universidad de Navarra, Medical School, University of Navarra, Pamplona, Spainen_US
dc.identifier.citationFuente-García Carlota, Muñoz-Negrete Francisco José, de Dompablo Elisabet, Moreno-Montañés Javier, Rebolleda Gema. Changes in ocular surface after withdrawal of anti-glaucoma medications following non-penetrating deep sclerectomy. Indian Journal of Ophthalmology. 2022 May; 70(5): 1626-1633en_US
dc.identifier.issn1998-3689
dc.identifier.issn0301-4738
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/224294
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber5en_US
dc.relation.volume70en_US
dc.source.urihttps://doi.org/10.4103/ijo.IJO_2654_21en_US
dc.subjectGlaucomaen_US
dc.subjectKeratographen_US
dc.subjectnon?penetrating deep sclerectomyen_US
dc.subjectocular hyperemiaen_US
dc.subjectocular surface diseaseen_US
dc.titleChanges in ocular surface after withdrawal of anti-glaucoma medications following non-penetrating deep sclerectomyen_US
dc.typeJournal Articleen_US
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