Evaluation of immunogenicity and tolerance of single dose haemophilus influenzae type B (PRP-T) vaccine.

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dc.contributor.authorAcharya, Den_US
dc.contributor.authorDesai, Aen_US
dc.contributor.authorNanavaty, Nen_US
dc.contributor.authorPandit, Aen_US
dc.contributor.authorPatel, Ven_US
dc.contributor.authorShah, Jen_US
dc.contributor.authorShendurnikar, Nen_US
dc.contributor.authorSingh, Sen_US
dc.contributor.authorTaneja, Aen_US
dc.contributor.authorVani, Sen_US
dc.date.accessioned1995-10-01en_US
dc.date.accessioned2009-05-27T05:33:09Z
dc.date.available1995-10-01en_US
dc.date.available2009-05-27T05:33:09Z
dc.date.issued1995-10-01en_US
dc.description.abstractOBJECTIVE: Evaluation of immunogenicity and acceptability of PRP-T vaccine among the Indian children. DESIGN: Multicentric, open, parallel group, comparative study of Haemophilus influenzae type B vaccine, given as single (Group I) or associated (Group II) with DPT vaccine. SETTING: Five different vaccination clinics. SUBJECTS: 125 children between the age group of 18-24 months. PARAMETERS: Measurement of (i) pre and post vaccination antibody titres of Haemophilus influenze type B specific antibody; (ii) Adverse events; and (iii) Tolerance as graded by the physician. RESULTS: Prevaccination antibody levels were > 0.15 mcg/ml in 56.3% in Group I and 35.7% in Group II. Post-seroconversion was seen in 97% in Group II receiving single and all in Group II (P > 0.05). The vaccine was well tolerated. CONCLUSIONS: The probability of subclinical infection or cross immunity is high in India. ACTHIB vaccine has a good immunogenicity and tolerance and association with DPT does not modify the immunogenicity of ACTHIB vaccine.en_US
dc.description.affiliationDepartment of Pediatrics, King Edward Memorial Hospital, Pune.en_US
dc.identifier.citationAcharya D, Desai A, Nanavaty N, Pandit A, Patel V, Shah J, Shendurnikar N, Singh S, Taneja A, Vani S. Evaluation of immunogenicity and tolerance of single dose haemophilus influenzae type B (PRP-T) vaccine. Indian Pediatrics. 1995 Oct; 32(10): 1077-82en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/11646
dc.language.isoengen_US
dc.source.urihttps://indianpediatrics.neten_US
dc.subject.meshAntigens, Bacterial --blooden_US
dc.subject.meshDeveloping Countriesen_US
dc.subject.meshEvaluation Studies as Topicen_US
dc.subject.meshFemaleen_US
dc.subject.meshHaemophilus Infections --immunologyen_US
dc.subject.meshHaemophilus Vaccines --administration & dosageen_US
dc.subject.meshHaemophilus influenzae --immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshVaccinationen_US
dc.titleEvaluation of immunogenicity and tolerance of single dose haemophilus influenzae type B (PRP-T) vaccine.en_US
dc.typeClinical Trialen_US
dc.typeControlled Clinical Trialen_US
dc.typeJournal Articleen_US
dc.typeMulticenter Studyen_US
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