The effects of antibiotics on liver enzymes in pregnancy
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Date
2023-08
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Medip Academy
Abstract
Background: Antibiotics are increasingly being prescribed during pregnancy. Even though safe non-teratogenic drugs are prescribed, due to altered pharmacokinetics during pregnancy can have adverse effects on hepatic metabolism. Methods: This was a prospective analytical study conducted in the department of obstetrics and gynecology at ESIC Medical College and PGIMSR, Bengaluru, Bengaluru from August 2022 to January 2023, 62 pregnant women diagnosed with infection were admitted and evaluated for the effects of antibiotics on liver enzymes. All cases had undergone a baseline Liver function test before antibiotic therapy were compared and statistically analyzed with the liver enzymes, alanine transaminase (ALT), and aspartate transaminase (AST) values after 7 days of the antibiotic course. Results: In this study, the mean age of pregnant women enrolled was 26±3.62 years. Both primi (45.2%) and multigravida (54.8%) were equally represented. The most commonly prescribed antibiotic was cefotaxime (67.7%). The mean pre AST was 17.92±11.28 and post-AST was 18.34±15.55 U/l (paired t-test =0.861) and the mean pre-ALT was 13.09±19.82 and post-AST was 11.7±8.01 U/l (paired t-test =0.533). Hence there were no significant changes in post-AST and post-ALT compared to Pre AST and ALT values. Conclusions: In this study the common antibiotics administered were cephalosporins and they didn’t show any effects on AST or ALT values after completing the antibiotic course.
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Keywords
ALT, Antibiotics, AST, Pregnancy
Citation
Handu K., Prabhu S.. The effects of antibiotics on liver enzymes in pregnancy. International Journal of Research in Medical Sciences. 2023 Aug; 11(8): 2843-2847