A Comparative Study on Nebulised Levosalbutamol versus Adrenaline in Wheeze Associated Condition of Children Between 1 Month to 6 Months of Age Admitted in Paediatric Ward of a Tertiary Medical College during COVID-19 Pandemic
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Date
2024-10
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Publisher
THE INDIAN MEDICAL ASSOCIATION
Abstract
Background : It is seen that most wheezing episodes in infancy during the COVID-19 pandemic are of viral origin commonly diagnosed as Acute Viral Bronchiolitis, Pneumonia or Wheeze associated Respiratory Tract Infection. Previous trials have provided conflicting evidence regarding the benefit of bronchodilators like ?2 agonists, adrenaline, ipratropium bromide etc. It is proved that levosalbutamol is much safer alternative than salbutamol, but no clinical trial till date has assessed it's efficacy to nebulised adrenaline in wheezing episodes in infants. Thus this study will attempt to verify the efficacy of bronchodilators in wheeze associated respiratory conditions and assess the benefits of a ?-2 specific agonist versus combined ? and ? (non-specific) agonist among the first time wheezing infants during this COVID-19 pandemic. Materials and Methods : The study was conducted with 60 infants aged 1 month to 6 months of age attending the Paediatric Medicine Emergency Department of NRS medical college in Kolkata with first time wheeze. The study period was 1.4 years from March, 2020 to July, 2021. Of these 30 received nebulised levosalbutamol (0.1mg/kg/dose) (Group A) and remaining 30 were given adrenaline nebulisation (0.1mg/kg/dose in1:10,000 solution) (Group B) maintaining CDC COVID-19 protocol. In 3 doses of each drug were given along with O 2 at 15 mins interval. Respiratory rate, Respiratory Distress Assessment Index (RDAI) score, heart rate and pulse oximetry were recorded before intervention, just after 2nd dose, 30 mins after last dose and 1 hour after last dose. Results : Both adrenaline and levosalbutamol caused significant improvement in mean respiratory rate, RDAI score and oxygenation. However, the adrenaline group showed a significantly better improvement in study parameters than levosalbutamol group. Conclusion : The study concluded that nebulised adrenaline is signifantly superior to levosalbutamol in reliving symptoms in infants with wheeze.
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Keywords
Nebulised Levosalbutamol, Nebulised Adrenaline, Wheeze, COVID-19
Citation
Das Subhadipa, Sardar Subhasis, Basu Rajarshi, Mahapatra Tapan kumar Sinha . A Comparative Study on Nebulised Levosalbutamol versus Adrenaline in Wheeze Associated Condition of Children Between 1 Month to 6 Months of Age Admitted in Paediatric Ward of a Tertiary Medical College during COVID-19 Pandemic. Journal of the Indian Medical Association. 2024 Oct; 122(10): 55-59