Inhibition of proinflammatory cytokines and mediators by euphol.
| dc.contributor.author | Pandey, Anjali | |
| dc.contributor.author | Bani, Sarang | |
| dc.date.accessioned | 2014-06-02T06:38:32Z | |
| dc.date.available | 2014-06-02T06:38:32Z | |
| dc.date.issued | 2013-04 | |
| dc.description.abstract | The anti-inflammatory properties of Euphol (EU) a diterpene, isolated from the rhizomes of the plant Euphorbia acaulis, were evaluated. This study was designed to examine the effects of EU on inflammation in a rat model of pleurisy compared with a steroidal anti-inflammatory drug (DEX, dexamethasone). The rat model of pleurisy was used to evaluate the effectiveness of EU on leukocyte migration, exudation volume, proinflammatory cytokines i.e. Tumor Necrosis factor α (TNFα), Interleukin-1 (IL-1β) and Interleukin-6 (IL-6) as well as on proinflammatory mediators PGE2, nitrite/nitrate levels, and LTB4. Pleurisy was induced by carrageenan (cg ), administered by intra pleural route (i.pl.) and the leukocyte infiltration and inflammatory parameters analyzed 4 h after pleurisy induction. EU (8mg/kg-1, p.o.) treated groups caused significant decrease in the infiltration of neutrophils and exudate volume . There was an observed marked reduction in TNFα, IL-1β and IL-6 levels. Flow cytometric analysis of intracellular TNFα by leukocytes present in pleural exudates showed a significant decrease relative to the total extracellular TNFα inhibition in the pleural fluid. The proinflammatory mediators PGE2, LTB4 release and the nitrite/nitrate levels were remarkably deregulated which are interrelated to TNFα and IL-1β levels. | en_US |
| dc.identifier.citation | Pandey Anjali, Bani Sarang. Inhibition of proinflammatory cytokines and mediators by euphol. Journal of Applied Pharmaceutical Science. 2013 Apr; 3(4): 20-25. | en_US |
| dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/151591 | |
| dc.language.iso | en | en_US |
| dc.source.uri | https://www.japsonline.com/counter.php?aid=843 | en_US |
| dc.subject | Euphol (EU) | en_US |
| dc.subject | Rat pleurisy | en_US |
| dc.subject | Leukocytes | en_US |
| dc.subject | Proinflammatory Cytokines | en_US |
| dc.title | Inhibition of proinflammatory cytokines and mediators by euphol. | en_US |
| dc.type | Article | en_US |