Physical Activity Related Risk Factor Assessment for Altered Drug Pharmacokinetics in Human Population.

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dc.contributor.authorThomas, Abhilash
dc.contributor.authorSamanta, Malay Kumar
dc.contributor.authorDubey, Satendra K
dc.contributor.authorArun, K P
dc.date.accessioned2015-03-28T09:59:29Z
dc.date.available2015-03-28T09:59:29Z
dc.date.issued2014-07
dc.description.abstractThe study examined the intensity of an individual’s physical activity by using self administered International Physical Activity Questionnaire Short Form 7 (IPAQ-SF7) as a measuring tool and assessed its impact on the various body physiological functions likely to alter drug pharmacokinetic processes. The study was conducted in normal, subjects inhabited at different regions in India, with the translated versions of IPAQ-SF7 in Hindi and Tamil languages found the high intensities of vigorous, moderate activities and walking and showed excellent reproducibility as similar as it has been studied in different population worldwide. The resting state systolic and diastolic blood pressures, heart rate and respiratory rate were significantly higher in the subjects. The diaphragmatic breathing pattern was found used by majority of the subjects. The energy utilization of the subjects on their physical activity was obtained in high Metabolic Equivalence of Task (METs) minutes per week. Thus significance in the physiological parameters was strong enough to alter the pharmacokinetics of drugs whose metabolism and elimination are primarily dependent on renal function. This results which will be helpful in optimizing and selecting the drug doses for the people under extreme physical activity with less oxygen consumption in muscles, low level of respiratory rates and high energy utilization in their body.en_US
dc.identifier.citationThomas Abhilash, Samanta Malay Kumar, Dubey Satendra K, Arun K P. Physical Activity Related Risk Factor Assessment for Altered Drug Pharmacokinetics in Human Population. Indian Journal of Pharmaceutical & Biological Research. 2014 Jul-Sept ; 2 (3): 43-53.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/157318
dc.language.isoenen_US
dc.source.urihttps://ijpbr.in/pdf-september/8-Physical-Activity-Related-Risk-Factor-Assessment-for-Altered-Drug-Pharmacokinetics-in-Human-Population.pdfen_US
dc.subjectPhysical Activityen_US
dc.subjectInternational Physical activityen_US
dc.subjectQuestionnaire-Short Form 7en_US
dc.subjectReproducibility, Pharmacokineticsen_US
dc.subjectMetabolic Equivalence of Tasken_US
dc.subject(METs) minutes per weeken_US
dc.titlePhysical Activity Related Risk Factor Assessment for Altered Drug Pharmacokinetics in Human Population.en_US
dc.typeArticleen_US
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