Indicators of oxidative stress in thyroid cancer.

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dc.contributor.authorKoduru, Bhargav
dc.contributor.authorTejaswini
dc.contributor.authorThakur, Ajit
dc.contributor.authorKamath, Shobha U
dc.contributor.authorShenoy, Kallya Rajgopal
dc.contributor.authorKamath, Ullas
dc.contributor.authorReshma, K
dc.date.accessioned2011-11-14T05:39:39Z
dc.date.available2011-11-14T05:39:39Z
dc.date.issued2010-04
dc.description.abstractFerric reducing antioxidant power (FRAP), myeloperoxidase (MPO) activity and the levels of protein thiols and carbonyls were estimated in the blood samples of thyroid cancer patients (n = 20) before and after thyroidectomy, as well as in healthy controls (n = 10) to study the extent of damage caused by tumor tissue proliferation-induced oxidative stress and to ascertain that oxidative stress levels drop, when there was no proliferation. A significant decrease (p<0.001) in the levels of serum protein thiols and FRAP as well as a significant increase (p<0.001) in the levels of protein carbonyls and MPO activity in the blood of thyroid cancer patients before surgery was observed as compared to healthy controls. All the parameters studied also showed a significant difference (p<0.001) in their respective levels in thyroid cancer patients, pre- and post-thyroidectomy. These findings present the role of oxidative stress as a pathological implication of thyroid cancer.en_US
dc.identifier.citationKoduru Bhargav, Tejaswini, Thakur Ajit, Kamath Shobha U, Shenoy Kallya Rajgopal, Kamath Ullas, Reshma K. Indicators of oxidative stress in thyroid cancer. Indian Journal of Biochemistry & Biophysics. 2010 Apr; 47(2): 121-123.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/135255
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/8264/1/IJBB%2047%282%29%20121-123.pdfen_US
dc.subjectThyroid canceren_US
dc.subjectCarbonylen_US
dc.subjectThiolsen_US
dc.subjectMyeloperoxidaseen_US
dc.subjectFRAPen_US
dc.subjectFree radicalen_US
dc.subjectOxidative damageen_US
dc.subject.meshAntioxidants --metabolism
dc.subject.meshBiological Markers --blood
dc.subject.meshBiological Markers --metabolism
dc.subject.meshCase-Control Studies
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshOxidative Stress
dc.subject.meshPeroxidase --metabolism
dc.subject.meshProteins --chemistry
dc.subject.meshSulfhydryl Compounds --metabolism
dc.subject.meshThyroid Neoplasms --blood
dc.subject.meshThyroid Neoplasms --metabolism
dc.subject.meshThyroid Neoplasms --surgery
dc.subject.meshThyroidectomy
dc.titleIndicators of oxidative stress in thyroid cancer.en_US
dc.typeArticleen_US
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