The hepatitis C virus persistence: how to evade the immune system?

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dc.contributor.authorPavio, Nicoleen_US
dc.contributor.authorLai, Michael M Cen_US
dc.date.accessioned2003-04-08en_US
dc.date.accessioned2009-06-01T14:13:47Z
dc.date.available2003-04-08en_US
dc.date.available2009-06-01T14:13:47Z
dc.date.issued2003-04-08en_US
dc.description163 references.en_US
dc.description.abstractHepatitis C virus (HCV) is an emerging virus of medical importance. A majority of HCV infections become chronic and lead to chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. HCV usually induces robust immune responses, but it frequently escapes the immune defense to establish persistent infection. The fact that HCV exists as an evolving quasispecies plays an important role in the selection of escape mutants. Furthermore, several viral proteins interfere with cellular functions, in particular, those involved in the immune response of the host. Several HCV proteins also modulate cell signalling through interaction with different effectors involved in cell proliferation and apoptosis, or in the interferon-signalling pathway. In addition, HCV infects immune cells such as B and T cells, and thus affects their normal functions. These various strategies used by HCV to counter the immune response of the host are reviewed here. A better understanding of these mechanisms would help design new therapeutic targets.en_US
dc.description.affiliationDepartment of Molecular Microbiology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA.en_US
dc.identifier.citationPavio N, Lai MM. The hepatitis C virus persistence: how to evade the immune system? Journal of Biosciences. 2003 Apr; 28(3): 287-304en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/110680
dc.language.isoengen_US
dc.source.urihttps://www.ias.ac.in/jbiosci/index.htmlen_US
dc.subject.meshEpitopes --metabolismen_US
dc.subject.meshHepacivirus --geneticsen_US
dc.subject.meshHepatitis C --immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmune System --physiologyen_US
dc.subject.meshSignal Transductionen_US
dc.subject.meshViral Proteins --immunologyen_US
dc.titleThe hepatitis C virus persistence: how to evade the immune system?en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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