Comparison effect of Pioglitazone and Glimepiride alone on renal function marker in experimentally induced renal damage in diabetic rats.
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Date
2011-04
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Abstract
Present study was designed to evaluate in Renoprotective activity of Pioglitazone and
Glimepiride on Ischemia/reperfusion (I/R) induced renal damage in diabetic rats.
Ischemia/reperfusion injury, which is commonly seen in the field of renal surgery or
transplantation in diabetic condition, is a major cause of acute renal failure. Type 2 Diabetes was
induced in rats by a single intraperitoneal (i.p) injection of Streptozotocin (65 mg/kg, STZ) in
overnight fasting rats followed by the i.p administration of Nicotinamide (110 mg/kg, NIC) after
15 minutes. After right nephrectomy, Piogltazone (10 mg/kg/day, p.o) and Glimepiride (0.5
mg/kg/day, p.o) were administered for 15 days. On the 16th day, ischemia was induced in contra
lateral kidney for 45 min, followed by reperfusion for 24 hr. renal function marker and oxidative
parameter were estimated at the end of 24 hr reperfusion. At the end of experimental period the
level of malondialdehyde formation/ lipid peroxidation (LPO) in kidney tissue and serum marker
Creatinine, Urea and Uric acids were significantly increased. Whereas, the activity of biomarkers
of oxidative stress such as reduced glutathione (GSH), Catalase (CAT) and superoxide dismutase
(SOD) were found to be decreased significantly compared to control rats. Pioglitazone improved
the renal dysfunction and oxidative stress after renal ischemia/reperfusion injury in diabetic rats,
but Glimepiride less improved the renal marker change compared to treatment of Pioglitazone.
In conclusion, Pioglitazone shows potent may improve renal function marker and oxidative
stress in kidney in I/R induced renal damage in type 2 diabetic rats.
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Pioglitazone, renal ischemia reperfusion injury, Renal marker, type 2 diabetes
Citation
Kakadiya Jagdish, Shah Nehal. Comparison effect of Pioglitazone and Glimepiride alone on renal function marker in experimentally induced renal damage in diabetic rats. Journal of Applied Pharmaceutical Science. 2011 May; 1(3): 72-76.