Development, Evaluation and Stability Studies of Zidovudine and Lamivudine (ZILA) Tablet Dosage Form.

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dc.contributor.authorSingh, Vikramjit
dc.contributor.authorAlam, Nawazish
dc.contributor.authorSharma, Monika
dc.contributor.authorAlam, Md. Sarfaraz
dc.contributor.authorAli, Md. Sajid
dc.contributor.authorAlam, Md. Intakhab
dc.date.accessioned2014-05-27T12:38:34Z
dc.date.available2014-05-27T12:38:34Z
dc.date.issued2012-09
dc.description.abstractTablets containing zidovudine and lamivudine (ZILA) were prepared by direct compression method. Optimization studies were done for the selection of glidant, lubricant and coating materials. Evaluation of granuleswere done on the basis of preformulation studies. The prepared tablets were evaluated for physicochemical properties. The in- vitro release studies were performed as per USP and compared with marketed product. The release of zidovudine and lamivudine were analysed by high performance liquid chromatography (HPLC). The ZILA tablets exhibited better release characteristics than the marketed product. Stabilities studies were performed in both blister as well as cold form blister packings. Stabilities studies revealed the suitability of blister package in comparison to the cold form blister packing. From the study it was concluded that the selected composition can be used for the preparation of tablets that can be used for the treatment of HIV-1 and Hepatitis-B after performing studies on animals for its suitability and efficacy.en_US
dc.identifier.citationSingh Vikramjit, Alam Nawazish, Sharma Monika, Alam Md Sarfaraz, Ali Md Sajid, Alam Md Intakhab. Development, Evaluation and Stability Studies of Zidovudine and Lamivudine (ZILA) Tablet Dosage Form. Journal of Applied Pharmaceutical Science. 2012 Sept; 2(9): 149-154.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/151405
dc.language.isoenen_US
dc.source.urihttps://www.japsonline.com/counter.php?aid=650en_US
dc.subjectZidovudineen_US
dc.subjectLamivudineen_US
dc.subjectHIVen_US
dc.subjectDirect compressionen_US
dc.subjectBlister packingen_US
dc.titleDevelopment, Evaluation and Stability Studies of Zidovudine and Lamivudine (ZILA) Tablet Dosage Form.en_US
dc.typeArticleen_US
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