Comparison of Analgesic Efficacy of Piroxicam and Ketorolac in Impacted Mandibular Third Molar Surgery: A Prospective Randomized, Double Blind Clinical Study
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Date
2024-11
Journal Title
Journal ISSN
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Publisher
Society for Health Care & Research Development
Abstract
Background: Postoperative pain following third molar extraction is said to be one of the most acute postsurgical painful conditions with patients require some form of analgesic to deal with it. This study examined the clinical efficacy of piroxicam and ketorolac in managing pain and swelling after lower third molar extraction. Material & Methods: This randomized controlled study was conducted among 24 patients requiring trans-alveolar mandibular molars extraction. GROUP A (12 patients) who were given a single dose of 20 mg piroxicam orally. GROUP B (12 patients) who were given 10 mg ketorolac QID orally. Pain and swelling was evaluated on 1st, 3rd, 7th, and 14th post-operative day. Results: The two study groups were comparable by age and gender. The mean (SD) pain score was lower in Group A (Piroxicam) as compared to Group B (Ketorolac) on Day 1 and 3 and it was found to be statistically significant (p<0.001). There was no significant difference in the mean (SD) pain score between the two groups by Day 7 and 14 of follow up. There was statistically significant reduction in swelling in Group A patients on Day 1, 3 and 7 as compared to Group B patients (p<0.001) but by Day 14 no statistically significant difference in swelling reduction was detected across the two groups. Conclusions: Both piroxicam and ketorolac were effective in reducing postoperative pain and swelling following removal of mandibular third molars with piroxicam showing better control in early postoperative days.
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Keywords
Impacted third molar, Ketorolac, Piroxicam, Pain, Swelling.
Citation
Sharma Shubham, Gupta Amit, Nongmaithem Jason, Awana Kajal, Ghosh Shayan, Dua Piyush . Comparison of Analgesic Efficacy of Piroxicam and Ketorolac in Impacted Mandibular Third Molar Surgery: A Prospective Randomized, Double Blind Clinical Study. Annals of International Medical and Dental Research. 2024 Nov; 10(6): 1-7